The Intrinsic Function and Structure in Multiple Sclerosis (IF-SIMS) Study

Notice Type: Sources Sought Synopsis: THIS IS NOT A REQUEST FOR PROPOSAL. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals, nor will any award be made as a result of this Sources Sought Notice. Any information provided by businesses to the Government is strictly voluntary. The Government will NOT be responsible for any costs incurred by interested businesses responding to this Sources Sought Notice. Contact with other than 502d Contracting Squadron personnel by potential offerors or their employees regarding this notice is prohibited. The purpose of this notice is to conduct market research only. The Department of Defense Military Treatment Facilities (MTF) in San Antonio, Texas has a requirement for non-personal services; The Intrinsic Function and Structure in Multiple Sclerosis (IF-SIMS) Study, to include but not limited to the following services: a. Provide derivation of pluripotent stem cells and subsequent differentiation and analysis of cells provided from skin biopsies. b. Derive, purify, and validate IPSC lines from skin punch biopsy or blood samples, and further differentiate these cells to various CNS cell types (validated with immunocytochemistry and/or gene expression), then perform single-cell transcriptions or additional phenotype analysis on these cell types. c. Provide all data and analysis to the principle investigator. Work shall be performed in accordance with the attached Statement of Work (SOW) dated 26 April 2017, contractor shall comply with all federal, state, and local environmental laws, rules, and regulations. The 502d Contracting Squadron anticipates issuing sole source award for a Firm Fixed Price (FFP) contract. The solicitation and subsequent amendments will be publicized through the Federal Business Opportunities (FedBizOpps) website at www.fbo.gov. Contractors are solely responsible for monitoring the Internet to download the solicitation and any subsequent amendments. Paper copies and/or electronic mail of the solicitation and any subsequent amendments will not be provided under any circumstances. Prospective offerors shall have a current System for Award Management (SAM) registration prior to contract award. Interested businesses should respond to the questions presented within this Sources Sought Notice in order to facilitate the Government's market research efforts. The Government will analyze all responses and determine the business strategy for this acquisition. Any questions relating to this notice must be submitted in writing, via email ONLY and solely to the Points of Contact listed in this notice. The submission should address all questions in the Sources Sought questionnaire below and your firm's ability to perform the requirement. Prospective offerors interested in this opportunity shall respond to this Sources Sought Notice by email ONLY to SrA Kelsey Inscoe, Contract Administrator at kelsey.inscoe@us.af.mil or SSgt Justin Holden, Contracting Officer at justin.holden.1@us.af.mil by 11:00 AM (CST) on 15 May 2017. Sources Sought Questionnaire 1. Point of Contact: Company: Address: Company Website Address: CAGE Code: Primary NAICS: Small Business? What socioeconomic categories are you self-certified/certified for? Point of Contact: Phone Number: Email Address: 2. A capability statement that explains what type of work your company has experience performing. Please provide information on whether or not your company can fill all of the requirements described in the SOW. Technical capabilities may be submitted in your own format and shall be 10 pages or less. 3. Recommendations on handling of work that cannot be easily quantified. 4. Any best practices from previous contracts that may be relevant and suggestions to maximize effectiveness in providing quality services to Joint Base San Antonio. Attachment: Statement of Work (SOW), 1 page, dated: 26 April 2017 Statement of Work The Intrinsic Function and Structure in Multiple Sclerosis (IF-SIMS) Study 26 April 2017 I. Description of Requirements: The contractor will provide product and services in support of Wilford Hall Ambulatory Surgery Center Protocol: FWH201700I3H, The Intrinsic Function and Structure in Multiple Sclerosis (IF-SIMS) Study. 2. The contractor: a. Shall provide derivation of pluripotent stem cells and subsequent differentiation and analysis of cells provided from skin biopsies for 16 subject samples within 1 hour of sample collection to preserve cell viability and survivability without cryopreservation. b. Shall derive, purify, and validate IPSC lines from skin punch biopsy or blood samples, and further differentiate these cells to various CNS cell types (validated with immunocytochemistry and/or gene expression) and then perform single-cell transcriptome or additional phenotype analysis on these cell types. c. Provide all data and analysis to the principle investigator and permit principle investigator to directly participate in the testing processes 3. The government a. Shall provide de-identified skin punch biopsies or blood samples to contractor for the requested services. b. Shall only receive the data and analysis provided by the contract services and processes described above.