This Pre-Solicitation opportunity from Department Of Health And Human Services was posted on July 27, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.
Whole brain mouse light sheet brain imaging service
Contract Overview
Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.
AI Contract Overview
The contract secures a whole-brain light-sheet imaging service for genetically modified mouse lines maintained by the Section on Neural Circuits at the NIAAA, NIH, to enable precise quantification of brain activity changes across genotypes. Accurate and timely imaging is critical to the validity of downstream experimental analyses, as phenotypic differences cannot be assessed without reliable data on whole-brain activity patterns. Samples, prepared and shipped by the Lead Project Manager and trainees, are processed by clearing tissue and performing high-resolution light-sheet imaging, followed by segmentation into over 820 anatomical regions. Resulting datasets include both raw and area-normalized cell counts delivered in CVF files, with all data transferred to an NIH-provided hard drive. The service requires strict adherence to a one-month turnaround from sample receipt due to age-sensitive experimental timelines. The vendor must receive, log, clear, image, segment, and deliver data for each brain sample while retaining both the processed data and physical samples for at least one year to support retesting or validation. All tasks—from sample receipt to data shipping—are governed by the need for precision, consistency, and compliance with NIH standards. The contract is issued under solicitation number 75N98026Q00887 by LifeCanvast Technologies Inc. for performance in Bethesda, Maryland, with Vishnuvajjala Hanumanth Rao as the primary point of contact, and responds to a presolicitation posted in July 2026 with a response deadline in August 2026.
General Info
Agency
NAICS
Place of Performance
Bethesda, MD, 20892, USASet-Aside
Timeline
Submission Closed
Organization & Contact Information
Full Description
The imaging service will be used to analyze changes in whole brain activity from genetically modified mouse lines maintained by the Section on Neural Circuits at the NIAAA, NIH. Accurate imaging of brain activity is essential it forms the foundation for all downstream experimental analyses. Without this information, we cannot proceed with our experiments, as the validity of our data depends on the ability to quantify phenotypic differences based on genotype.
Rapid turnaround is also critical, as some experiments are age-sensitive and require genotyping results within 1 month of sample receipt. The brain tissue samples to be processed by clearing and light sheet imaging will be collected by the Lead Project Manager (LPM), and trainees in the Section on Neural Circuits at the NIAAA.
Whole brains are shipped to the company in tubes. The company processes the samples by clearing the tissue and performing light-sheet imaging. The brain is segmented into over 820 regions, and CVF files containing both raw counts and counts per area are provided. Results must be delivered within one month of sample arrival. Data are shipped to us on an NIH-supplied hard drive, and both the results and brain samples are retained by the company for at least one year to allow for any necessary retesting.
The following tasks are required to fulfill this requirement:
Receive and log incoming brain samples.
Perform tissue clearing and prepare samples for imaging.
Conduct whole-brain light-sheet imaging.
Segment the brain into defined anatomical regions (>820 areas).
Generate CVF files with raw and normalized cell counts.
Transfer data to an NIH-provided hard drive and ship to the research team.
Maintain archived data and physical samples for a minimum of one year.
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