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CRESTONE, INC.

UEI: EDSLAP2J1BL8CAGE: 5RDJ6

CRESTONE, INC. is a federal contractor, registered under UEI EDSLAP2J1BL8 and CAGE code 5RDJ6. It has been awarded $67,610,270 across 12 federal contracts. Primary work spans Research and Development in Biotechnology (except Nanobiotechnology), Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology), and Unknown NAICS. Top awarding agencies include Department Of Health And Human Services and Other agencies (2 agencies, <0.5% each).

Contact Information

Registration and classification details

Registration

UEI Code

EDSLAP2J1BL8

CAGE Code

5RDJ6

Entity Structure

Corporate Entity (Not Tax Exempt)

Established

N/A

Business Classifications

2X

NAICS Codes

541714Research and Development in Biotechnology (except Nanobiotechnology)
541715Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)(Primary)

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

AI Capability Profile

CRESTONE, INC. specializes in preclinical and clinical-stage research and development across the life sciences, with deep expertise in small-molecule drug discovery, laboratory synthesis, and translational bioassay validation. The company supports federal agencies by advancing novel therapeutic cand...

CRESTONE, INC. specializes in preclinical and clinical-stage research and development across the life sciences, with deep expertise in small-molecule drug discovery, laboratory synthesis, and translational bioassay validation. The company supports federal agencies by advancing novel therapeutic candidates from early-stage optimization through Investigational New Drug (IND) filing readiness, employing rigorous biochemical, pharmacological, and analytical methodologies. Their technical capabilities include medicinal chemistry synthesis, in vitro and in vivo testing protocols, pharmacokinetic/pharmacodynamic profiling, and regulatory-compliant data package development for NIH and VA programs. CRESTONE differentiates itself through its focused execution in biotechnology and physical sciences R&D, particularly in bridging laboratory innovation with clinical development pathways under strict federal compliance frameworks. The contractor maintains a consistent presence with the Department of Health and Human Services, primarily supporting National Institutes of Health initiatives in infectious disease and therapeutic development, as well as the Department of Veterans Affairs, where they deliver specialized laboratory services for biomedical research. These relationships reflect a pattern of sustained engagement in mission-critical, science-driven programs requiring precision, reproducibility, and regulatory alignment. CRESTONE operates primarily under NAICS 541714 and 541715, focusing on non-nanotechnology biotechnology research and broader physical/engineering life sciences R&D. Their market positioning centers on niche, high-impact therapeutic discovery efforts, particularly in small-molecule optimization and preclinical validation, serving the federal biomedical innovation ecosystem without competing in broad-spectrum contract research. As a small business structured as a 2L entity based in Boulder, Colorado, CRESTONE operates with agility and scientific rigor. The company holds no formal government certifications but leverages its technical depth and domain-specific experience to deliver high-value R&D services within the federal life sciences market.

Key Performance Metrics

Awards Count

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Award Analytics & Distribution

Awards by Agency
Department Of Health And Human Services$67.3M99.6%
Other agencies (2 agencies, <0.5% each)$291.1K0.4%
Awards by NAICS
Export
541714 - Research and Development in Biotechnology (except Nanobiotechnology)$33.5M49.5%
541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)$22.0M32.6%
- Unknown NAICS$6.1M9.1%
541711 - Research and Development in Biotechnology$5.9M8.8%
Awards by Agency Over Time
Export
Awards by Place of Performance

Open opportunities in CRESTONE, INC.'s top NAICS codes and agencies

NAICS: 541715
New
Federal
REQUEST FOR WHITE PAPERS BAA TOPIC: Topic 13. Biotechnology, “Controlling polymicrobial environments as a strategy for defeating harmful organisms while promoting the growth of beneficial organisms”
Solicitation # W912CG-26-S-BIOTECH
The U.S. Army Combat Capabilities Development Command Soldier Center is soliciting white papers under Broad Agency Announcement W911QY-25-R-0023 to advance biotechnological research focused on controlling polymicrobial environments to suppress harmful organisms while fostering beneficial ones, with specific emphasis on developing phage-based hygiene wipes to prevent urinary tract infections in female Warfighters. The effort aims to design, optimize, and test a cosmetic-grade formulation that maintains bacteriophage viability under extreme thermal conditions—particularly at 45°C for four weeks—while being compatible with natural cellulosic wipes, resealable packaging, and regulatory standards under the Modernization of Cosmetic Regulation Act. The proposed formulation must include a phage cocktail at a minimum titer of 1E8 PFU/ml, a neutral pH buffer, preservatives effective at pH 7–8, stabilizers like polyvinyl alcohol, and moisturizing agents, all without compromising phage activity. Up to three formulation iterations are expected, culminating in the delivery of 100 prototype wipe packs—50 with active phage and 50 without—for field-relevant testing. Submission begins with a white paper, limited to five pages, detailing the technical approach, management structure, relevant past performance, and a rough order of magnitude cost estimate covering a 12-month base period with two optional 12-month extensions. Only white papers submitted electronically by 31 August 2026, 5:00 p.m. EDT, to the designated email address will be considered eligible for further invitation to submit a full proposal. Evaluation will prioritize scientific merit, management capability, alignment with Army mission needs, and cost-effectiveness, with feedback provided to submitters. Selection of white papers does not guarantee funding or a contract award, as decisions are contingent on budget availability and program priorities. The government reserves the right to cancel the solicitation at any time without obligation. Award mechanisms may include a contract, grant, or cooperative agreement, though a contract is the intended outcome. Formal proposals will only be requested from top-scoring white papers, and no further communication with government technical personnel is permitted after submission of a full proposal.
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NAICS: 541715
New
Federal
Airborne and Mobile Measurements to support NOAA ARL’s Research on Meteorology and Atmospheric Chemistry
Solicitation # 145022-26-0017
The contract solicits specialized airborne and mobile measurement services to support NOAA’s atmospheric research in key urban regions, including Washington DC/Baltimore and New York City, with additional focus on methane emissions characterization and boundary layer analysis using mobile ceilometers and drone-mounted analyzers. The contractor must provide fully equipped research aircraft, qualified flight crews, and operational support to conduct multiple research flights in compliance with FAA regulations, collecting high-quality meteorological, chemical, and navigational data that will be integrated with NOAA’s existing aircraft, satellite, and surface monitoring systems. Also required is the deployment of a mobile ceilometer for continuous planetary boundary layer height measurements and, when requested, FAA-compliant unmanned aircraft systems equipped with methane/ethane analyzers to quantify point source emissions. The effort includes analysis of mobile laboratory data collected during the 2026 SOCCER-AQ field campaign in Boston to identify and quantify urban emission sources, compare observations with emissions inventories and models, and produce peer-reviewed publications and conference presentations. Administrative coordination is a core component, with the prime contractor responsible for managing all subcontractors, overseeing financial and scheduling milestones, consolidating deliverables, and ensuring full compliance with contract terms through a firm fixed-price, all-or-none award. This is a small business set-aside under NAICS code 541715, with a performance period from September 1, 2026, to August 31, 2027, and payment terms of Net 30. All work is centered at NOAA’s Advanced Systems and Modeling Division in Riverdale Park, Maryland, with deliverables due by the end of the period of performance. Quotes must be submitted electronically by August 14, 2026, to the designated NOAA point of contact, and pricing must be provided in accordance with the SF18 form or company letterhead, including monthly and annual breakdowns. The government explicitly states it will not accept responsibility for non-receipt of quotes, and the awardee must confirm receipt. Wage determinations referenced under WD #2015-4265 and WD #2015-4187 apply, and administrative coordination responsibilities—including subcontract management, invoice processing, and final documentation—must be fulfilled by the prime contractor, though technical oversight of scientific tasks remains with NOAA and subcontractors. All contract provisions and clauses are accessible via acquisition.gov, and the solicitation does not require SAM representations that are not included in the official solicitation documents.
Department Of Commerce Noaa

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NAICS: 541715
New
Federal
AJ11--(Late) Research Services - ID Neuroimaging Biomarkers for Brain Connectivity - BRONX | EDA: 9/25/26
Solicitation # 36C24E26R0022
The Department of Veterans Affairs, James J. Peters VA Medical Center, intends to award a sole-source contract to the New Jersey Institute of Technology (NJIT) for specialized research services focused on identifying neuroimaging biomarkers for brain connectivity, in support of an ongoing VA Merit Award. This action is justified under 41 U.S.C. §3304(a)(3) and FAR 6.103-3, as NJIT is the only entity with the unique, four-year-developed expertise, proprietary datasets, and validated methodologies essential to the research's continuity and scientific integrity. NJIT’s world-class proficiency in fNIRS-based brain connectivity research, backed by multiple peer-reviewed publications and sustained collaboration with VA investigators, cannot be replicated by other institutions, even those with fNIRS capabilities, due to the absence of proximity, shared data infrastructure, and proven technical proficiency. Any other source would introduce unacceptable delays or compromise the research outcomes. The solicitation number is 36C24E26R0022, with a posted date of August 5, 2026, and a deadline for capability statements of August 10, 2026, at 4:00 PM EST. While this is a notice of intent and not a competitive solicitation, any responsible source believing it can meet the requirement may submit a capability statement to Lynn Portman at lynn.portman@va.gov by the deadline; telephone responses are not accepted. The NAICS code is 541715, and the contracting office is located in Pittsburgh, PA, under the Rpo East (36C24E) organization. The government retains sole discretion to determine whether to proceed without competition, and no further opportunities for bid submission will be provided.
Rpo East (36C24E)

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NAICS: 541715
New
Federal
ARMY OPEN SOLICITATION (AOS)
Solicitation # W9128Z-25-S-A002
The Army Open Solicitation (AOS), identified by solicitation number W9128Z-25-S-A002, is an indefinite, open solicitation issued by the U.S. Army Contracting Command – Aberdeen Proving Ground to rapidly acquire innovative commercial technologies and research-driven solutions across all Army mission areas. Designed to revitalizing the industrial base and enhancing Warfighter lethality, the solicitation leverages a flexible acquisition framework under multiple FAR, DFARS, and U.S. Code authorities, including Other Transactions, Commercial Solutions Opening, and prototype authorities. It supports both Active Capability Gap submissions and periodic Calls for Solutions, with responses evaluated based on technical merit, feasibility, schedule, price estimation, viability, and desirability using a trade-off approach rather than lowest price technically acceptable. The solicitation remains open indefinitely until canceled, with recent amendments through March 2026 expanding and clarifying Army Example Areas, refining submission procedures, and updating contracting information including Active Capability Gap mailboxes. All submissions must adhere to strict formatting requirements, including a single PDF submission not exceeding five pages or fifteen slides, with mandatory inclusion of an executive summary, company information, and rough order of magnitude cost and schedule estimates. Offerors must be registered in SAM, use WAWF for invoicing, and comply with stringent data storage and security requirements, including U.S.-only data hosting and full organizational conflict of interest disclosures. The solicitation encourages participation from small businesses, nontraditional defense contractors, and nonprofit research institutions, with specific certifications required through the Affirmation of Business Status Certification. Performance may occur at government facilities including Aberdeen Proving Ground and other CONUS/OCONUS locations as directed, with award timing anticipated in fiscal year 2026, and support expected through 2032. No fixed contract value is provided, as pricing is determined through competitive evaluation of commercial proposals under the solicitation's open-ended structure.
W6QK Acc-Apg Cont Ct Software Sector

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NAICS: 541715
New
Federal
ATEC HQ 002 - Wide-Field Optical Data Fusion Modernization
Solicitation # ATEC_RIW26_002
The Army Contracting Command - Aberdeen Proving Ground, acting on behalf of the Army Test and Evaluation Command, has issued a Call for Solutions to advance Wide-Field Optical Data Fusion Modernization under solicitation number ATEC_RIW26_002. This initiative seeks innovative technical approaches to enhance the integration and processing of wide-field optical data, targeting improvements in operational effectiveness and system performance. Submissions must adhere to the guidance detailed in the CfS document and align with the overarching framework of the Army Open Solicitation W9128Z-25-S-A002. All communications regarding this solicitation must include the specific subject line format: “Call for Solution - [Your Company Name] - ATEC_RIW26_002” to ensure proper routing and processing. The deadline to submit questions is August 10, 2026, at 1500 EDT, and all proposals for Phase 1 are due by August 19, 2026, at 1500 EDT. The solicitation is managed by the Department of Defense through the ACC-APG office located in Aberdeen Proving Ground, Maryland, with primary point of contact Dennis Beauclair, Jr., and secondary contact Whitney J. Jackson. Proposers are directed to review both the Call for Solutions and the associated Army Open Solicitation posting for complete requirements, evaluation criteria, and submission protocols. Responses must be submitted through the designated SAM.gov portal linked in the official posting.
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NAICS: 541715
New
Grant
US Travelers Health Research, Surveillance, Communication, and Outreach Network
Solicitation # RFA-CK-26-036
The Centers for Disease Control and Prevention is seeking to establish a comprehensive network to enhance the health and safety of U.S. travelers internationally by improving pre-travel preparedness, real-time health information access, and rapid research capacity. The initiative focuses on empowering both travelers and healthcare providers with up-to-date, high-quality travel health guidance through scalable digital platforms including electronic medical records, web applications, and mobile tools. These technologies will facilitate the systematic collection of health data before, during, and after travel to identify emerging risks and support timely public health responses. The program aims to strengthen the role of primary care providers in travel medicine by expanding their awareness and equipping them with evidence-based tools to deliver accurate recommendations to international travelers. The network will serve as a foundational platform for ongoing surveillance and research into global health threats affecting U.S. travelers, enabling proactive identification and mitigation of infectious and environmental risks. By integrating data from diverse sources and fostering collaboration across healthcare systems, the project seeks to create a dynamic, responsive infrastructure that informs both individual travel decisions and broader public health policy. This effort is being issued under solicitation RFA-CK-26-036 with a submission deadline of November 5, 2026, and is managed by the CDC within the U.S. Department of Health and Human Services, with inquiries directed to the designated point of contact.
Centers For Disease Control And Prevention

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NAICS: 541715
New
Federal
Sensory and Nutrient Data Integration Framework DevelopmentThe contract seeks the design and implementation of a data integration system that merges sensory evaluation data with quantitative nutrient assay results to support predictive shelf-life modeling. This effort is focused on creating a unified framework capable of harmonizing disparate data streams from sensory panels and laboratory nutrient analyses, enabling advanced modeling to forecast product degradation over time. The work must ensure compatibility, accuracy, and scalability for use in research and operational environments where food integrity and longevity are critical. The system must be built to support future expansion and interoperability with existing data platforms. This is a Small Business Set Aside subcontract under NAICS code 541715, issued by the NASA Shared Services Center on behalf of the National Aeronautics and Space Administration. The place of performance is in Houston, Texas, with a response deadline of August 11, 2026, and the solicitation was posted on August 4, 2026. The effort requires expertise in data science, chemical analysis, sensory science, and system architecture, with a strong emphasis on delivering a robust, maintainable solution that directly supports NASA’s mission-critical needs in food systems and long-duration spaceflight. Only small business concerns eligible under the SBA guidelines may respond.
NASA Shared Services Center

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NAICS: 541714
New
Federal
Evaluation of a Lead NNMT Inhibitor in Humanized M
Solicitation # 75N98026Q00941
The National Institutes of Health, Office of the Director, intends to award a non-competitive, firm-fixed price contract to GemPharmatech LLC for the evaluation of a lead NNMT inhibitor using a humanized nicotinamide N-methyltransferase mouse model, a model uniquely developed and maintained by GemPharmatech under prior NIH funding. This acquisition is conducted under streamlined commercial item procedures and is not expected to exceed the simplified acquisition threshold, with authority derived from FAR 12.603 and 41 U.S.C. 1901, and justified under the sole source exception for unique capabilities, as GemPharmatech is the only entity with the cryopreserved sperm and breeding resources necessary to regenerate the required mouse colony essential for generating scientifically relevant efficacy data due to the inhibitor's species-specific activity. The solicitation number is 75N98026Q00941, issued as a combined synopsis and solicitation without competitive procedures, and responses are due by August 19, 2026. The work falls under NAICS code 541714 for Research and Development in Biotechnology with a small business size standard of 1,000 employees, and this requirement is not set aside for small business. The contract will be managed by the NIH Office of Acquisitions based in Bethesda, Maryland, with the primary point of contact being Johnstona C. Johnston, reachable via email. All provisions and clauses follow those in effect through the Federal Acquisition Circular dated August 4, 2026, and the notice serves as the complete and only solicitation document; no additional written solicitation will be issued. The performance location is not specified beyond the federal agency's administrative details.
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