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Reference-Number-SN04-003Federal

Contract Overview

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Researchers at the National Institute of Standards and Technology (NIST) are developing advanced techniques for the controlled self-assembly of phospholipid vesicles, or liposomes, within continuous two-phase flow microfluidic channels. Unlike traditional bulk mixing methods that produce liposomes with variable size and structure, this approach utilizes precise manipulation of liquid flow rates in a planar microfluidic network to achieve uniform liposome formation. This method enables the production of liposomes with sizes ranging from 100 nm to 300 nm, improving homogeneity and control over polydispersity by creating a stable and controllable solvent-aqueous interface at the scale relevant to liposome formation. The research has significant implications for encapsulating reagents in quantized packets that mimic cellular processes, potentially enhancing the quality and reproducibility of liposome-based technologies. Although this is not a contract or grant announcement, inquiries regarding the technology can be directed to the Office of Technology Partnerships at NIST, located in Gaithersburg, Maryland. The project is referenced under docket number 04-003US and highlights NIST’s ongoing efforts to innovate in microfluidics and nanotechnology applications.

General Info

NIST develops microfluidic methods for uniform liposome production with controlled size and improved homogeneity.

Agency

Department Of Commerce Nist

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Documents

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Timeline

PostedMay 3

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Organization & Contact Information

AgencyDepartment Of Commerce Nist

ContactsNo contacts available

OfficeGAITHERSBURG, MD, 20899, USA

Organization / AgencyDepartment Of Commerce Nist

Office AddressGAITHERSBURG, MD, 20899, USA

ContactsNo contact information available

Full Description

DEVELOPMENTS AT NIST Researchers at the National Institute of Standards and Technology (NIST) are working on the following technologies. FOR FURTHER INFORMATION, CONTACT THE: NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, OFFICE OF TECHNOLOGY PARTNERSHIPS, 100 BUREAU DRIVE, STOP 2200, GAITHERSBURG, MARYLAND 20899; FAX: +1 (555) 000-0000. This is not an announcement of a contract action or a grant. *** NIST DOCKET NUMBER: 04-003US Title: Controlled Vesicle Self-Assembly in Continuous Two Phase Flow Microfluidic Channels Description: The spontaneous self-assembly of phospholipids into liposomes in aqueous solution results in the encapsulation of reagents into quantized packets in a manner that mimics cellular life-processes. Traditional liposome preparation methods are conducted through mixing of bulk phases, leading to inhomogeneous chemical and/or mechanical conditions during liposome formation; hence liposomes are often polydisperse in size and lamellarity. The formation of liposomes that encapsulate reagents in a continuous 2-phase flow planar microfluidic network with precision control of size, over the range of 100 nm to 300 nm, by manipulation of liquid flow rates is shown. Creating a solvent-aqueous interfacial region in a microfluidic format that is homogenous and controllable on the length scale of a liposome demonstrates the facilitation of fine control of liposome size and polydispersity. ***