This Pre-Solicitation opportunity from Department Of Health And Human Services was posted on August 25, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Assay Service for assessing ADME properties and in vivo PK properties with the selected vendor.

Closed

75N98026Q01083ENAMINEYSINCFederal

Submission Closed09/03/2026, 01:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 424690

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Purchasing

POSTED

1 day ago

DEADLINE

in 9 days

AI Contract Overview

The National Institutes of Health (NIH) is seeking chemical reagent assay development and laboratory testing services to support the Section on Medicinal Chemistry in developing new molecular entities for metabolic and alcohol-associated diseases. The primary objective is to assess the translational potential of these compounds through a series of derisking assays. This includes grouped ADME assays such as Caco-2 Permeability to predict oral absorption, CACO and MDCKR assays for brain penetrance, hERG assays for cardiac toxicity, and plasma stability and binding tests to evaluate behavior in bodily fluids. The highest performing compounds will then undergo in vivo pharmacokinetic studies in C57BL6 mice to determine oral availability. This procurement is currently a pre-solicitation notice of intent, conducted under FAR Part 13 Simplified Acquisition Procedures, with a total value not exceeding the simplified acquisition threshold of 350,000 dollars. The government is evaluating whether to proceed with a non-competitive award to Enamine US Inc. or to conduct a competitive procurement. Interested parties must submit a technical proposal, cost-price proposal, period of performance, Unique Entity ID, Taxpayer Identification Number, and business size certification to the NIH Office of Logistics and Operations in Bethesda, Maryland.

General Info

NIH seeks vendor for chemical reagent assay development and laboratory testing services.

Agency

Department Of Health And Human Services → National Institutes Of Health Olao

NAICS

424690 - Other Chemical and Allied Products Merchant Wholesalers

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

Documents

Notice of Intent - VISHNU ENAMINE NIAAA 08396

special-notice

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedAug 25

Presolicitation

Response DeadlineSep 3

Deadline has passed

Submission Closed

09/03/2026, 01:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Contacts1 person available

OfficeBETHESDA, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

Office AddressBETHESDA, MD, 20892, USA

Contacts

Vishnuvajjala Hanumanth Rao

contact@example.gov

Full Description

Assay Service for assessing ADME properties and in vivo PK properties with the selected vendor.

The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed with the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available.

Request to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability. CACO and MDCKR assays allow to know the brain penetrance of the compounds. hERG assays allow to know if the compounds will show cardiac toxicity. The plasma stability and binding show how the compounds behave in bodily fluids. Finally, the best compounds then undergo testing in mice to know if they can be given orally and thus have translational potential in human testing. These assays are integral to the work of section on medicinal chemistry at NIAAA as these enable to progress compounds for further development as therapeutics in metabolic and alcohol use disorders.