This Sources Sought opportunity from Department Of Health And Human Services was posted on April 29, 2022. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Assessment of Tobacco Product Pharmacology/Toxicology and Human Behaviors in Tobacco Users

Closed

FDA-2022-112034Federal

Submission Closed05/20/2022, 07:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

New

Federal

Mouse PK/PD Study Services for NNMT Inhibitors

Solicitation # 75N98026Q00993

The National Institutes of Health, Office of the Director, Office of Acquisitions, is seeking proposals for Mouse PK/PD Study Services for NNMT Inhibitors under solicitation number 75N98026Q00993, issued as a combined synopsis and solicitation under FAR Subpart 12.6 to streamline the procurement of commercial services. The government intends to award a firm-fixed-price contract through full and open competition, with no set-aside, to the offeror providing the best value. This acquisition falls under NAICS code 541715 for Research and Development in the Physical, Engineering, and Life Sciences, with a small business size standard of 1,000 employees, and is not expected to exceed the simplified acquisition threshold. Proposals must be submitted by the deadline of August 24, 2026, and all terms are governed by the Federal Acquisition Circular effective August 7, 2026. The point of contact for inquiries is Johnstoun, Jaddua C, reachable via email at jaddua.johnston@nih.gov, with performance expected to occur at the NIH office in Bethesda, Maryland.

National Institutes Of Health Olao

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Preclinical Rodent Toxicity Study Execution

National Institutes Of Health Olao

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System Integration and On-Site Installation SupportThe contract seeks on-site technical support to integrate the ENDOR system with the existing Bruker EPR infrastructure at the United States Air Force Academy, located in Colorado Springs, Colorado, with a zip code of 80840. This effort includes comprehensive commissioning and validation activities to ensure seamless operation and full functionality of the integrated system within the current experimental setup. The work requires specialized expertise in electron paramagnetic resonance systems and must be performed directly at the facility to align with operational protocols and hardware specifications. The contract is classified as a subcontract under NAICS code 541715, which corresponds to research and development in the physical, engineering, and life sciences. It was posted on August 7, 2026, with a response deadline of August 14, 2026, at 8:00 PM Eastern Time. The contracting activity is under the Department of Defense, specifically the FA7000 10 Cons Lgc office, and work must be conducted on-site at the USAF Academy location. No set-aside provisions are specified, and all proposers must meet the technical and logistical demands of performing complex system integration in a military research environment.

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DEADLINE

Digital Pulse Control System DevelopmentA subcontract has been issued for the development of a digital control system designed to generate and synchronize highly complex ENDOR pulse sequences with nanosecond precision using high-resolution arbitrary waveform generators. This effort is focused on advancing the capabilities of electronic nuclear double resonance technology by ensuring exact timing and coordination of pulses critical for high-fidelity magnetic resonance applications. The work is to be performed at the US Air Force Academy in Colorado Springs, Colorado, with a contract classification under NAICS code 541715 for research and development in physical, engineering, and life sciences. The solicitation was posted on August 7, 2026, and responses are due by August 14, 2026, indicating a tight timeline for proposal submission. The contract is part of a Department of Defense initiative, though no specific set-aside or organizational type is identified, suggesting it is open to qualified contractors without restriction based on size or certification status.

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Confidential Research Reporting and AnalysisThe contract requires the generation of detailed scientific reports focused on univariate and multivariate correlation analyses of drug response patterns across a panel of cell lines, ensuring rigorous analytical standards and adherence to strict confidentiality protocols. All work must comply with NCATS publication restrictions, meaning results cannot be publicly disclosed or published without explicit authorization, and all data handling must preserve the proprietary and sensitive nature of the underlying biological and pharmaceutical information. The project is structured as a subcontract under the National Institutes of Health, operating within the Department of Health and Human Services, with the NAICS code 541715 indicating it falls under scientific research and development services. The solicitation was posted on August 7, 2026, with a response deadline of August 24, 2026, and performance is expected to be carried out under the oversight and guidelines of the NCATS program, though no specific location or point of contact is provided.

National Institutes Of Health Olao

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PRISM Pooled Cancer Cell Line Assay ExecutionThe contract calls for the execution of a 5-day Luminex-format viability assay using the PRISM platform to evaluate a compound’s effect across approximately 900 barcoded cancer cell lines. The assay will utilize an 8-point, 3-fold dilution series to generate dose-response data, enabling precise measurement of cellular viability under varying concentrations of the compound. All work must be conducted with high technical rigor to ensure the generation of high-quality, reproducible viability data suitable for downstream analysis. The deliverables include comprehensive viability profiles for each cell line and detailed correlation analyses that link compound sensitivity to cellular and genetic characteristics across the panel. The project is structured as a subcontract under the National Institutes of Health, part of the Department of Health and Human Services, with the North American Industry Classification System code 541715 indicating it falls under research and development in the physical, engineering, and life sciences. The solicitation was posted on August 7, 2026, and responses are due by August 24, 2026.

National Institutes Of Health Olao

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DEADLINE

Daikin Chiller Recommissioning and Firmware UpgradeThe contract involves the recommissioning of three 200-ton Daikin air-cooled chillers, requiring comprehensive services including firmware upgrades, precise sensor calibration, integration with the building automation system, and thorough operational and safety verification. These tasks are essential to restore optimal performance, ensure system reliability, and align the chillers with current operational standards. The work is to be performed at a specified location in Aurora, Colorado, with a zip code of 80011, and all activities must comply with industry best practices for HVAC recommissioning. This is a subcontract classified under the Small Business Set Aside program, specifically designated for small businesses, with a NAICS code of 541715 indicating professional, scientific, and technical services related to scientific and technical consulting. The solicitation was posted on August 7, 2026, with responses required by August 13, 2026, at 6:00 PM. The contracting agency is the Department of Defense under the FA2543 460 Cons office, and while the full organizational details and point of contact are not provided, the place of performance and set-aside classification establish clear parameters for eligible contractors seeking to respond.

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Custom HDL Plugin Development for Signal ProcessingThe contract requires the development of custom HDL plugins derived from Xilinx reference designs to implement ADC and DAC passthrough functionality, enabling seamless real-time signal processing workflows. The work must align with established hardware architectures to ensure compatibility and performance in high-speed data acquisition and processing environments, with a focus on low-latency, deterministic operation critical for defense and research applications. The deliverables will include fully verified HDL code, integration support, and documentation to facilitate deployment within existing systems. This subcontract is issued by the Naval Research Laboratory under the Department of Defense, with performance required at a location in Washington, D.C., ZIP code 20036. The solicitation, classified under NAICS code 541715 for scientific research and development services, is open for responses until August 11, 2026, with submissions due by 8:00 PM Eastern Time. The project demands expertise in FPGA design, digital signal processing, and adherence to Xilinx toolchains, targeting advanced signal analysis capabilities for naval and defense systems.

Naval Research Laboratory

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DEADLINE

ADC/DAC Configuration Software and JESD204C IntegrationThe contract requires the development of software to initialize registers for analog-to-digital and digital-to-analog converters and to integrate the JESD204C high-speed serial interface for RF data acquisition and transmission on FPGA platforms. The solution must ensure precise configuration of ADC and DAC components and reliable, low-latency data transfer compliant with the JESD204C standard, enabling high-performance signal processing in defense applications. The work involves close alignment with FPGA architecture, timing constraints, and protocol implementation to support mission-critical RF systems. The contract is a subcontract issued by the Naval Research Laboratory under the Department of Defense and is classified under NAICS code 541715 for research and development in the physical, engineering, and life sciences. The place of performance is identified as Washington, DC, with a zip code of 20036. The opportunity was posted on August 7, 2026, and responses are due by August 11, 2026, at 8:00 PM Eastern Time. The solicitation does not specify a set-aside classification or point of contact, and further details are accessible through the provided SAM.gov link.

Naval Research Laboratory

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DEADLINE

HDL Reference Design and Plugin DevelopmentThe contract requires the development of HDL reference designs and plugin files to facilitate seamless integration of custom algorithms on the VCK190 and VA601 platforms, specifically targeting AXI4-Stream and AI Engine interfaces. The work involves creating modular, reusable hardware descriptions and software plugins that enable efficient data flow and control between proprietary algorithms and the target FPGA hardware, ensuring compatibility with Xilinx’s streaming protocol and AI Engine architecture. The deliverables must support rapid deployment and validation of machine learning and signal processing functions on these platforms without requiring major redesigns of existing systems. The contract is listed as a subcontract under the Naval Research Laboratory, part of the Department of Defense, with a posting date of August 7, 2026, and a response deadline of August 11, 2026. Performance is expected to be centered in Washington, DC, with a zip code of 20036. The NAICS code 541715 indicates this is a research and development service in the computer systems design field, emphasizing the technical nature of the work. While no specific point of contact or set-aside details are provided, the focus remains on advancing defensive technology through hardware-software co-design tailored for high-throughput, low-latency signal processing applications.

Naval Research Laboratory

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Technical Support & Manufacturer Warranty Services

NASA Shared Services Center

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Research & Development – Advanced Technology PrototypingThis contract pertains to advanced technology prototyping under a DARPA-managed research and development initiative, focusing on technical development that integrates systems engineering, algorithm design, and hardware-software co-design. It is structured as a subcontract with a multi-phase execution approach, requiring innovative solutions that push the boundaries of current capabilities in defense-related technologies. The work will involve iterative prototyping and demonstration of novel systems, with each phase building on the outcomes of the prior one to validate technical feasibility and operational relevance. The opportunity is open for responses until October 19, 2026, and is classified under NAICS code 541715 for research and development in the physical, engineering, and life sciences. Performance is expected to be conducted under the auspices of the Department of Defense, though specific location details are not defined. The contract is part of a broader effort to accelerate the transition of cutting-edge research into practical prototypes, with an emphasis on rapid development cycles and cross-disciplinary collaboration. Respondents must demonstrate expertise in high-risk, high-reward technology development aligned with DARPA’s strategic goals, and proposals are expected to address scalability, manufacturability, and potential for operational deployment.

Defense Advanced Research Projects Agcy

POSTED

2 days ago

DEADLINE

in 2 months

General Info

Agency

Department Of Health And Human Services → FDA Center For Tobacco ProductsView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

MD, USA

Set-Aside

NONE

Documents

(1)

sources+sought+Human+Pharmacology.pdf

PDF

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Timeline

PhaseClosed

PostedApr 29

Sources Sought

Response DeadlineMay 20

Deadline has passed

Submission Closed

05/20/2022, 07:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → FDA Center For Tobacco Products

Contacts1 person available

OfficeSilver Spring, MD, 20993, USA

Organization / Agency

Department Of Health And Human Services → FDA Center For Tobacco Products

View Agency Profile

Office AddressSilver Spring, MD, 20993, USA

Contacts

Lisa Jackson

contact@example.gov

Full Description

The U.S. Food and Drug Administration (FDA), Office of Acquisitions and Grants Services (OAGS) is conducting market research to support the Center for Tobacco Products (CTP) requirement for services to evaluate the impact of tobacco products on human behavior, switching behaviors, topography, pharmacology and toxicology outcomes. The FDA is requesting capabilities per the attached Sources Sought Notice. This is not a request for proposals and is only for market research purposes only