INTRODUCTION This is a pre-solicitation non-competitive (notice of intent) synopsis to award a contract without providing for full or open competition (including brand-name). THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR PROPOSAL. A SOLICITATION WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institute on Drug Abuse (NIDA), Consolidated Station Support and Simplified Acquisitions (CSS/SA) Branch intends to negotiate and award a purchase order to Yale University. The purpose of this purchase order is to determine the different bindings of PANDAS/PANS serum to D1- and D2-MSNs, TANs, FSis and N-NOS interneurons after subchronic in vivo infusion into the mouse stiatum. In addition, to determine whether this pattern is qualitatively and quantitatively altered following IVIG with clinical improvement. NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE The intended procurement is classified under NAICS code 611310 with a Size Standard of $25,500,000.00. REGULATORY AUTHORITY The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-82. STATUTORY AUTHORITY This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements. DESCRIPTION OF REQUIREMENT The Contractor shall perform a detailed characterization of sera collected from children with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)/Pediatric Autoimmune Neuropsychiatric Disorder associated with Streptococcus (PANDAS), and matched healthy controls. Characterization will be by in vivo infusion of sera into the brains of transgenic mice followed by cell type-specific immunohistochemical characterization, as described to the International OICD Foundation. The work will consist of 5 pairs of sera, one PANS/PANDAS and one matched control in each case. Key Personnel Requirements: The minimum education requirements for the Key Personnel supporting this potential requirement are an MD and P.h.D. degree neuroscience. In addition, the Contractor must have a minimum of 15 years' experience in behavioral and systems, cognitive learning and memory and molecular and cellular neuroscience. Finally, the Contractor must have expertise in both in vivo and in vitro experimentation. Anticipated Period of Performance: The anticipated period of performance of this firm fixed price contract will be one (1) twelve-month base period. CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, Yale University is the only vendor in the current market place that can provide the unique services required by the National Instute of Mental Health. In accordance with FAR part 10, extensive market research was conducted to reach this determination. Specifically, a small business sources sought notice was posted to FedBizOpps referencing the above detailed generic requirements and one response was received. Additionally, knowledgeable inviduals in the Government and Industry were contacted for market research purposes. None of the subject matter experts contacted were able to identify any contractor other than Yale University which could meet the needs of this requirement. Finally, a review of both the GSA Advantage and Dynamic Small Business Search returned no results. Therefore, only Yale University is capable of meeting the needs of this requirement. The intended source is: Yale University 105 Wall Street New Haven, CT 06511-6614 APPLICABLE CLAUSES AND PROVISIONS FAR 52.213-4, Terms and Conditions - Simplified Acquisitions The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. CLOSING STATEMENT THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by the closing date and time of this announcement and must reference the solicitation number. Responses may be submitted electronically to Paul Marsalese, Contract Specialist, at
contact@example.gov. US Mail and Fax responses will not be accepted.
