Collaborative Program Grant for Interdisciplinary Teams (RM1 Clinical Trial Optional)

The Collaborative Program Grant for Interdisciplinary Teams (PAR-27-003) is a Notice of Funding Opportunity issued by the National Institutes of Health, specifically involving the National Institute of General Medical Sciences, the National Institute of Dental and Craniofacial Research, and the National Institute on Deafness and Other Communication Disorders. This solicitation supports interdisciplinary research teams of three to six Program Directors/Principal Investigators tasked with addressing ambitious and challenging scientific goals that require significant synergy and cannot be achieved through individual efforts. The program emphasizes Team Science, requiring a highly integrated structure and interdependent collaboration. While clinical trials are optional, any proposed trial must include a detailed study timeline and comply with registration requirements on ClinicalTrials.gov. Applications are evaluated based on the interdependence of project components, the cohesion of the team integration plan, leadership and management structures that ensure shared decision-making, and the adequacy of institutional resources. Required submission materials include a Research Strategy consisting of a Program Description, Team Integration Plan, and Summary Table, as well as a Data Management and Sharing Plan. Applicants must maintain active registrations in the System for Award Management and eRA Commons. The funding opportunity features multiple application cycles starting from November 17, 2026, and continuing through September 26, 2029. Awardees must also adhere to strict cybersecurity guidelines, including the development of an incident response plan and a 48-hour notification window for any cybersecurity incidents.