This Pre-Solicitation opportunity was posted on August 27, 2013. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Development of a mouse model for Merkel Cell Carcinoma

Awarded

NCI-130119-TKFederal

Submission Closed09/10/2013, 04:00:00 PM UTC

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NAICS: 541380

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AI Contract Overview

The National Cancer Institute Dermatology Branch intends to award a firm fixed price contract for the development of a mouse model for Merkel Cell Carcinoma. The project aims to study the effects of Merkel Cell Polyomavirus large T antigen using an inducible system to better understand the mechanisms of this aggressive disease. The scope of work involves the creation of two specific mouse models, requiring the use of proprietary TARGATT technology to ensure efficient gene insertion into a defined locus. The selected contractor will be responsible for DNA pronuclear microinjection into the C57BL6 mouse strain, the generation of specific constructs and integrase, and the ongoing breeding, housing, and genotyping of the animals. The period of performance is one year from the date of award. While the NCI plans to procure these services from Applied Stem Cell on a sole source basis, interested parties may submit proposals by September 10, 2013.

General Info

Agency

N/A

Contract Value

$33,100

NAICS

541380 - Testing Laboratories and Services

Place of Performance

MD, USA

Set-Aside

NONE

Awardee

APPLIED STEMCELL, INC.

Award Issued Date

09/25/2013, 12:00:00 AM UTC

Documents

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Timeline

PhaseAwarded

PostedAug 27

Presolicitation

AwardedSep 25

Contract was awarded

Submission Closed

09/10/2013, 04:00:00 PM UTC

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Organization & Contact Information

AgencyN/A

Contacts1 person available

OfficeN/A

Organization / Agency

N/A

Office AddressN/A

Contacts

Tiffany D. Kittrell

contact@example.gov

+1 (555) 000-0000

Full Description

Title: Development of a mouse model for Merkel Cell Carcinoma Document Type: Presolicitation Notice Solicitation Number: NCI-130119-TK Proposed Posted Date: August 27, 2013 Proposed Response Date: September 10, 2013 Classification Code: B-Special studies and analysis NAICS Code: 541380- Testing laboratories Business Size Standard: $14 Million Description The National Cancer Institute (NCI) Dermatology Branch plans to procure on a sole source basis the services to develop a mouse model of Merkel Cell Carcinoma from Applied Stem Cell at 1165 O'Brien Drive, Suite A Menlo Park, CA 94025. The products herein are being procured in accordance with the simplified acquisition procedures as authorized by FAR Part 13.106-1 (b) (1). The North American Industry Classification System code is 541380 and the business size standard is 14 million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. Period of Performance: One year from the time of award. The NIH, NCI, Dermatology Branch, Cutaneous Development and Carcinogenesis Section, work on Merkel Cell Carcinoma as well as studying normal Merkel Cell development and Merkel Cell Stem cells in skin. Mouse models are powerful means of studying skin tissue, and the laboratory has many mouse models to study normal Merkel Cell development in skin. The two mice NCI would like to have generated will be very useful in studying Merkel Cell Carcinoma. Specifically, by crossing these mice NCI will be able to study the effect of Merkel Cell Polyomavirus large T antigen under the control of the Cytokeratin 18 promoter in an inducible system. This system will be important for further understanding of the mechanisms involved in Merkel Cell Polyomavirus T antigen driven cancers and will provide a model for further study of pathways involved in the development of this aggressive disease. The purpose of this acquisition is to develop a mouse model of Merkel Cell Carcinoma which is critical for further study of the pathways involved in the development of this disease. This project requires the use of TARGATT technology. TARGATT, which is proprietary technology to Applied Stem cell, was developed specifically for introducing gene(s) of interest into mammalian cell lines. The unique advantage of this system is that any gene can be inserted efficiently into a defined, transcriptionally-active locus with high gene expression in a single copy fashion. Tasks shall include: - The contractor shall perform DNA pronuclear microinjection of our BAC clone into the C57BL6 mouse strain (MOUSE #1 KI/KO PROJECT (BAC) ) - The contractor shall provide breeding, housing, care, and genotyping for this BAC mouse project - The contractor shall make a TARGATT vector using a TetO-oncogene that will be provided by our lab - The contractor shall generate AttB-TetO-Oncogene construct, and confirm the construct by enzyme digestion and sequencing, as well as purifying the construct and verifying its purity. (MOUSE #2 TARGATT PROJECT) - The contractor shall generate TARGATT integrase - The contractor shall do TARGATT DNA pronuclear microinjection into the C57BL6 mouse strain - The contractor shall provide animal housing, care, and genotyping during the course of this project. B. Reports : At the completion of each milestone, the contractor shall send a written report to the Brownell Laboratory. In addition, the contractor shall communicate weekly via email/phone to maintain continuity. For Mouse #1 KI/KO project (BAC) the report shall include Mouse generation steps (client is providing the targeting vector construct to ASC). For Mouse #2 TARGATT project, the reports shall include: - DNA construct design, schematic map, sequence and restriction enzyme digestion results; - Generation of Integrase mRNA, microinjection, embryo implantation and Quality Control; - Generation of transgenic mouse/mice and genotyping data This is not a solicitation for competitive quotations. However, if any interested party, especially a small business, believes they can meet the above requirement, they may submit a proposal. All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. The proposal must be received at the NCI Office of Acquisitions on or before 11:00 AM EST on September 10, 2013. All responses and questions must be in writing and can be faxed +1 (555) 000-0000 or emailed to Tiffany Kittrell, Contract Specialist at contact@example.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) through sam.gov. No collect calls will be accepted. Please reference solicitation number NCI-130119-TK on all correspondences.