Title: Metabolomic profiles and pancreatic cancer Document Type: Presolicitation Notice Solicitation Number: NCI-130143-TK Proposed Posted Date: August 26, 2013 Proposed Response Date: September 9, 2013 Classification Code: B-Special studies and analysis-not R&D NAICS Code: 541380 Business Size Standard: $14 Million Description: The Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), of the National Cancer Institute (NCI) plans to procure on a sole source basis to obtain Metabolomic profiles and pancreatic cancer from Metabolon Inc at 110407 Research Triangle Park, North Carolina 27709. The products herein are being procured in accordance with the simplified acquisition procedures as authorized by FAR Part 13.106-1 (b) (1). The North American Industry Classification System code is 541380 and the business size standard is $14 million. Only one award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. Period of Performance: One year from the time of award. Metabolomics is a field of research devoted to the study of large numbers (400-800) of small molecules within biofluids, such as blood. Metabolomic profiles incorporate exposure from diet, lifestyle, the environment and genetics, among many other factors, that may be related to cancer risk. The Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), of the National Cancer Institute (NCI) is conducting a metabolome-wide association study (MWAS) using serum samples collected prospectively in a nested case-control study of pancreatic cancer. The aim of the study is to identify metabolites associated with pancreatic cancer risk. The purpose of this procurement is to use metabolomics to identify biomarkers related to pancreatic cancer. The NCI will send 266 serum samples from pancreatic cancer case and control participants and quality control samples from the ATBC Study cohort. Samples are to be run using the Orbitrap Mass-Spectrometry (MS) platform, with linkage of raw MS output to named and unnamed biochemicals. Metabolon Inc. has conducted similar analyses on pancreatic cancer cases and controls that will be pooled with the results from this acquisition. If the same method and laboratory is not used to measure metabolites, then we cannot combine the results from the two studies. For scientific comparability, it is critical that the metabolomic profiles be carried out at Metabolon, Inc. Contractor Requirements: 1.Store samples immediately in -80 degrees until ready for assays. 2.Measure metabolites using orbitrap MS on 266 ATBC samples. The samples will be sent boxed in batches of 32. All batches and samples within the batches should be assayed in the order provided by NCI. All samples will be sent at the same time. All analytical work performed by the contractor will be conducted under conditions of careful quality control and will follow the usual quality control procedures. All contractor internal quality control charts will be provided to NCI after the first batch and at completion of the work. NCI will review the data for the blinded quality control samples to assure that satisfactory reproducibility is being provided. 3.Link orbitrapMS output to named and unnamed biochemicals from a reference database. 4.Communicate to Contracting Officer's Representative (COR) immediately via email or phone call if any problems. The contractor shall notify the COR immediately via e-mail or phone call if any unusual problems develop over the course of the project and/or explanations for repeating analyses, such as failure of analytical and quality control procedures, breakdown of freezers, instrumentation and equipment, and major changes in personnel that would produce delays or that would adversely influence the quality of the laboratory performance. 5.Deliver data to the NCI COR as tables of named and unnamed biochemicals and relative concentrations. This will be delivered by e-mail as either an Excel file or text file. 6. After the assays are run on each batch, residual samples will be stored in the laboratory at -80 degrees Centigrade. All biological materials provided by the U.S. Government, all residual specimens, and all data generated shall be the property of the U.S. Government and shall be returned to the U.S. government repository after the assays are completed and data approved by COR. This is not a solicitation for competitive quotations. However, if any interested party, especially a small business, believes they can meet the above requirement, they may submit a proposal. All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. The proposal must be received at the NCI Office of Acquisitions on or before 4:00 PM EST on September 9, 2013. All responses and questions must be in writing and can be faxed
+1 (555) 000-0000 or emailed to Tiffany Kittrell, Contract Specialist at
contact@example.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA) through sam.gov. No collect calls will be accepted. Please reference solicitation number NCI-130143-TK on all correspondences.
