This Government Contract opportunity from Department Of Health And Human Services was posted on May 13, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.
DNA Extraction and Shotgun Metagenomics Sequencing of Fecal Samples
Contract Overview
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The National Institutes of Health has issued a Notice of Intent to negotiate a sole source contract with Rush University Medical Center for DNA extraction and shotgun metagenomics sequencing of fecal samples. This acquisition involves processing 200 fecal samples, including samples from humans and mice both at baseline and post dietary interventions (ketogenic diet with or without NR supplementation for humans, and high fat diet with or without NR supplementation for mice). The objective of this work is to generate data supporting cross-species validation of mechanisms related to bile acid and FXR-driven ketogenesis. The required services include DNA extraction, library preparation, and shotgun metagenomics sequencing, followed by delivery of the raw data files to the Principal Investigator, Dr. Katherine Maki. The procurement will be conducted under authority permitting other than full and open competition due to a determination that only one responsible source can meet the agency’s requirements. Although this is not a request for proposal, other capable entities may submit a capability statement by May 23, 2026, for government consideration. The contract will be performed in Bethesda, Maryland, under NAICS code 622110, with oversight by the Department of Health and Human Services.
General Info
Agency
NAICS
Place of Performance
Bethesda, MD, 20892, USASet-Aside
Timeline
Submission Closed
Organization & Contact Information
Full Description
This is a Notice of Intent, not a request for proposal. The National Institute of Health intends to negotiate on an other than full and open competition basis with the following vendor: Rush University Medical Center.
Acquisition Description:
This acquisition requested is for DNA extraction and shotgun metagenomics sequencing of fecal samples from humans (n=25) at baseline and after a ketogenic diet with/with NR supplementation (n=100 samples), and from mice (n=25) at baseline and after a high fat diet with/with NR supplementation (n=100 samples; total 200 samples). The results from these tests will be used to understand cross-species validation of mechanisms related to bile acid- and FXR-induced increases in ketogenesis.
Services are required of (1) conducting shotgun metagenomics sequencing of fecal samples for 200 samples (including DNA extraction, library preparation and shotgun metagenomics sequencing) and (2) providing raw data files to the PI, Dr. Katherine Maki.
The statutory authority for this sole source requirement is 41 U.S.C. 253(c) (1) as implemented by FAR 6.302-1 only one responsible source and no other supply of service will satisfy agency requirements. THIS IS NOT A REQUEST FOR PROPOSAL. All responsible sources that could provide the required may submit a capability statement that will be considered by email (subject line to reference NOI-CC-OLAO-26-005551) by 12:00 PM eastern standard time on 05/23/2026 to: valerie.gregorio@nih.gov.
All responses received by the closing date of this synopsis will be considered by the Government. A determination not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government.