This Government Contract opportunity from Department Of Health And Human Services was posted on September 8, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.
IDENTIFY Study Participants – 5-Base Sample Preparation and Whole Genome Multiomic Profiling
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The National Institutes of Health, specifically the Prenatal Genomics and Therapy Section within the National Human Genome Research Institute, is seeking 5-base whole genome sequencing services for plasma-derived cell-free DNA samples from the IDENTIFY study. The project requires 5Base sample preparation and multiomic profiling at 30x coverage to generate high-resolution genomic and epigenomic data from women whose prenatal sequencing suggested maternal malignancy. The primary goal of this acquisition is to produce high-quality data to support computational models for determining the tissue source of incidentally detected maternal cancers. This effort aims to improve the interpretation of prenatal sequencing results, enhance early cancer detection during pregnancy, and advance the broader understanding of circulating cell-free DNA biology. The solicitation is identified as 75N98026Q01158 with a response deadline of September 15, 2026.
General Info
Place of Performance
Bethesda, MD, 20817, USASet-Aside
Timeline
Submission Closed
Organization & Contact Information
Full Description
The Prenatal Genomics and Therapy Section (PGTS), Center for Precision Health Research (CPHR), National Human Genome Research Institute (NHGRI), requires 5-base whole genome sequencing services for stored plasma-derived cell-free DNA samples collected under the IDENTIFY study. These samples were obtained from women who received prenatal cell-free DNA sequencing results suggestive of maternal malignancy. 5Base sample prep and whole genome multiomic profiling at 30x is required to generate high-resolution genomic and epigenomic data suitable for tissue-of-origin analyses.
The objective of this acquisition is to obtain high-quality, comprehensive 5-base sequencing data that will support the development and refinement of computational models to determine the tissue source of incidentally detected maternal cancers. The resulting data will be incorporated into ongoing bioinformatic and translational research efforts within PGTS to improve interpretation of prenatal cell-free DNA sequencing results, enhance early cancer detection strategies in pregnancy, and advance understanding of circulating cell-free DNA biology in the context of malignancy.
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