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This Government Contract opportunity from Department Of Defense was posted on April 8, 2022. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Effects of Pre-Dive Ketone Supplementation on Latency to CNS Oxygen Toxicity

Awarded
N00024-22-C-4323Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541714
New
Federal
Chemical, Biological, Radiological, and Nuclear (CBRN) Medical Countermeasure (MCM) Participant Basic Agreement (PBA)
Solicitation # W911SR-26-R-HEAL
The Capability Program Executive for Chemical, Biological, Radiological, and Nuclear Defense (CPE CBRND) is establishing the Chemical, Biological, Radiological, and Nuclear (CBRN) Medical Countermeasure (MCM) Participant Basic Agreement (PBA) ecosystem. This continuous, open announcement seeks to build a network of pre-qualified partners to accelerate the development, testing, and fielding of next-generation medical defense solutions. The program focuses on two primary pillars: host-targeted resilience, which targets critical host systems like neurological and respiratory pathways to enhance physiological protection, and threat-targeted neutralization, which focuses on broad-spectrum countermeasures for prophylaxis and acute treatment. Priority is given to candidates designed for austere environments, featuring environmental stability without cold-chain reliance and simplified administration routes such as oral or intranasal delivery. The government is inviting two types of participants: MCM Development Collaborators, ranging from Phase I products through FDA licensure, and MCM Development Support Collaborators, such as CROs and CDMOs specializing in preclinical testing, cGMP manufacturing, and regulatory submissions. Interested parties must submit a white paper of no more than five pages detailing their product descriptions, efficacy data, regulatory status, and manufacturing capabilities. Acceptance into the PBA enables the subsequent award of project orders under the authority of 10 U.S.C sections 4021, 4022, and 4023. These agreements are not subject to the Competition in Contracting Act of 1984. All prospective awardees must be registered in the System for Award Management (SAM) database to receive payment.
W6QK Acc-Apg

POSTED

1 day ago

DEADLINE

N/A
NAICS: 541714
New
Federal
AJ12--Development/Production - Kidney GEC-Specific AAV Vector
Solicitation # 36C24E27Q0009
The Department of Veterans Affairs is issuing a Sources Sought notice to identify capable vendors for the development and production of a kidney glomerular endothelial cell specific adeno-associated virus AAV vector. This project, funded by a VA ORD Merit award, aims to create a homing peptide enabled vector platform to target the glomerular endothelium to treat kidney injury and disease while reducing off target transduction. The scope of work is divided into three primary tasks: the engineering and incorporation of targeting peptides into the AAV capsid, testing vector binding and internalization in kidney tissue slices, and evaluating the specificity and efficiency of the modified vector through bioluminescence imaging and in vivo biodistribution studies. Qualified contractors must possess extensive onsite resources, including BSL 2 laboratories, specialized DNA and RNA facilities, and advanced instrumentation such as the Agilent Fragment Analyzer and various qPCR platforms. Vendors must demonstrate proven success in animal and human cell vector delivery and maintain full compliance with AAALAC and FELASA health standards. The government requires quarterly reporting, weekly videoconferences, and biannual face to face meetings. All generated data will be subject to Government Purpose Rights, and contractors must adhere to strict federal records management and information security protocols. Interested parties must submit a capability statement, relevant literature, and socio economic status details under NAICS 541714 by November 4, 2026.
Rpo East (36C24E)

POSTED

1 day ago

DEADLINE

in 13 days
NAICS: 541714
New
Grant
Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)
Solicitation # RFA-AI-28-012
The National Institute of Allergy and Infectious Diseases (NIAID) has issued solicitation RFA-AI-28-012 to establish a consortium of Translational Centers Using Microphysiological Systems for Infectious Diseases (TCMID). The primary objective is to refine and validate human tissue models using Microphysiological Systems (MPS) to a level consistent with regulatory qualifications, thereby promoting their adoption by product developers and reducing reliance on laboratory animals. This initiative aligns with NIH and FDA guidance on New Approach Methodologies (NAMs) to accelerate the development of safer medical interventions by capturing human variability and patient-specific characteristics. The program is structured around an Administrative Core, a Qualification Core, and Scientific Cores, with a heavy emphasis on technical readiness, reproducibility, and regulatory acceptance. Key deliverables include the validation of assays for specific endpoints and the submission of regulatory packages. Applicants must be domestic entities, as foreign organizations and foreign subawards are strictly prohibited. Required personnel must possess deep expertise in infectious diseases, MPS platforms, bioinformatics, and FDA submission processes. Applications are due by January 29, 2027, and must be submitted via the NIH ASSIST system or approved institutional system-to-system solutions. Evaluation is based on an overall impact score considering the project's significance, the suitability of the investigators, and the quality of the institutional environment. Mandatory application components include a Data Management and Sharing Plan and a Benchmarks and Timeline PDF not exceeding six pages. Awardees must also adhere to strict cybersecurity incident reporting guidelines, notifying HHS within 48 hours of any discovery.
National Institutes Of Health

POSTED

3 days ago

DEADLINE

in 3 months
NAICS: 541714
New
Grant
Immune Tolerance Network (UM1 Clinical Trial Required)
Solicitation # RFA-AI-28-005
The National Institutes of Health, under the Department of Health and Human Services, is seeking applications through solicitation RFA-AI-28-005 to continue the Immune Tolerance Network (ITN). This cooperative agreement aims to develop tolerogenic therapies for immune-mediated disorders, specifically focusing on autoimmune diseases, allergic diseases and asthma, and the immune-mediated consequences of transplantation. The network operates through four integrated functional areas: Leadership, Clinical Operations, Core Laboratory, and Bioinformatics. Its primary objectives include designing and conducting clinical trials, performing integrated mechanistic studies, and sharing research results. Eligible applicants include small businesses and other for-profit organizations, though non-domestic entities are ineligible. Applications are evaluated based on scientific and technical merit, with a primary focus on significance and the likelihood of exerting a sustained influence on the research field. Key requirements include maintaining active registrations in SAM.gov, eRA Commons, and Grants.gov, as well as adhering to strict cybersecurity incident reporting and human subject protection protocols. The project requires a minimum effort of 3.6 person months per year for the PD/PI and mandates participation in a kick-off meeting in Bethesda, Maryland, and bi-annual steering meetings. Applications must follow specific page limits for the research strategy subsections and include detailed plans for clinical trial implementation, data management, and biorepository services.
National Institutes Of Health

POSTED

3 days ago

DEADLINE

in 3 months

General Info

Contract Value

$825,248

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Durham, NC, 27708-4677, USA

Set-Aside

NONE

Award Issued Date

Documents

0

No documents available

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Uniform Contract Format

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Timeline

PhaseAwarded
Posted

Award Notice

Awarded

Contract was awarded

Submission Closed

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Organization & Contact Information

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AgencyDepartment Of Defense → Navsea Hq
Contacts1 person available
OfficeWASHINGTON NAVY YARD, DC, 20376-5000, USA
Office AddressWASHINGTON NAVY YARD, DC, 20376-5000, USA
Contacts

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Same awarding agency

NAICS: 334511
New
Federal
Navy Electronic Chart Display and Information System (ECDIS) Hardware and Software Production
Solicitation # N00025-26-R-5246
The U.S. Navy, through the Portfolio Acquisition Executive Mission Systems and Program Manager Warfighting / Applications (PMW/A 520), is soliciting proposals for the development, production, integration, testing, fielding, and lifecycle sustainment of the Electronic Chart Display and Information System (ECDIS) hardware and software. This full and open competition supports both surface and subsurface platforms, specifically focusing on the manufacture and assembly of AN/SYN-1 and Scalable Integrated Bridge System (S-IBS) hardware, alongside the maintenance and modification of software using Government Furnished Information. The contract is structured with one base year and four one-year option periods beginning in FY27, with an anticipated award in Q4 FY27. The procurement utilizes a best-value tradeoff process, prioritizing technical and management approaches over total evaluated cost and price. Hardware deliverables are primarily Firm Fixed Price with a stepladder pricing model based on quantity, while certain software and repair tasks are Cost Plus Fixed Fee Level of Effort. Offerors must maintain Secret facility and personnel clearances and adhere to strict cybersecurity, safety, and interoperability standards. Proposals are due by January 13, 2027, via the Procurement Integrated Enterprise Environment portal, and must include detailed technical, management, past performance, and cost volumes.
Search, Detection, Navigation, Guidance, Aeronautical, and Nautical System and Instrument Manufacturing

POSTED

about 13 hours ago

DEADLINE

in 3 months
View Details
NAICS: 336611
New
Federal
USS MAKIN ISLAND (LHD 8) FY28 Docking Selected Restricted Availability (DSRA) Request for Proposal(s)
Solicitation # N0002426R4421
The Naval Sea Systems Command (NAVSEA) is soliciting proposals for the USS MAKIN ISLAND (LHD 8) Fiscal Year 2028 Docking Selected Restricted Availability (DSRA). This Signature Availability is a comprehensive effort combining maintenance, modernization, and repair, requiring a contractor with substantial West Coast facilities, including a capable pier and dry dock. The project is expected to begin in November 2027 and reach completion by October 30, 2029. Due to the complexity and magnitude of the requirements, the procurement is not set aside for small businesses. The government intends to award a single Firm Fixed-Price contract based on best value using trade-off source selection procedures, with the award anticipated by March 2027. The scope of work encompasses extensive tasks including hull structure repairs, propulsion and electric plant maintenance, cabling, piping, and habitability upgrades. Evaluation will be based on technical eligibility, physical resource capacity, past performance, manpower, small business participation, and the proposed schedule and execution approach. The contract includes provisions for growth work, specifying 211,989 direct labor hours and over 9.5 million dollars in materials, along with a small dollar value growth incentive program. Proposals must be submitted electronically via PIEE, divided into a Price Volume and a Technical Volume, and must adhere to strict formatting and page limit requirements.
Ship Building and Repairing

POSTED

3 days ago

DEADLINE

in 2 months
View Details
NAICS: 334511
New
Federal
AN/BYG-1 Applications Re-Architecture
Solicitation # N0002426R6222
Solicitation N0002426R6222, issued by the Naval Sea Systems Command (Navsea HQ), seeks a contractor for the AN/BYG-1 Applications Re-Architecture. This effort involves the re-architecting of applications associated with the AN/BYG-1 system. The solicitation was posted on October 7, 2026, with a response deadline of November 5, 2026. The primary point of contact for the effort is Michael Ravnitzky, with Matthew C. Hedrick serving as the Contracting Officer. Due to the sensitive nature of the work, strict security and data handling requirements are in place. Offerors must possess a SECRET security clearance and provide a verified DD Form 2345 Military Critical Technical Data Agreement and a signed Terms of Use Agreement to access Government Furnished Information, source code, and technical documents. All data must be handled in accordance with NISPOM standards, and the transmission of information to foreign nationals or outside the United States is prohibited without a valid export license. Furthermore, the use of public cloud repositories or external AI tools for processing technical data is strictly forbidden. Contractors are required to destroy all provided data within 180 days of the RFP closing and maintain destruction records for five years.
Search, Detection, Navigation, Guidance, Aeronautical, and Nautical System and Instrument Manufacturing

POSTED

4 days ago

DEADLINE

in 14 days
View Details
NAICS: 333415
Federal
Shipboard Air Conditioning Plant System Sustainment Plan (SSP)
Solicitation # N0002427R4452
Navsea HQ is conducting market research under solicitation N0002427R4452 to identify capable sources for the Shipboard Air Conditioning Plant System Sustainment Plan (SSP). This initiative aims to standardize and scale the sustainment of centrifugal, reciprocating, and rotary air conditioning plants for U.S. Navy surface ships worldwide. The government is evaluating various acquisition strategies, including a single-award Indefinite Delivery, Indefinite Quantity (IDIQ) contract or multiple-source arrangements, to improve materiel condition and operational availability across diverse ship classes and geographic locations. The contemplated scope of work encompasses six primary capability areas: executing Major AC Plant Pit Stops and overseeing Minor Pit Stops, both of which must be completed within a mandatory six-week window; providing embedded AC&R technical expertise at Shore Intermediate Maintenance Activities (SIMAs) for Sailor training and oversight; supplying OEM AC plant materiel and repair parts; managing a global warehouse and rotable pool for Overhaul Parts Packages (OPPs); providing configuration-specific engineering, technical data, and integrated product support; and delivering global unplanned and emergent field services. Interested respondents must submit a response by October 28, 2026, including a completed Capability Certification Matrix and supporting evidence of their ability to perform these requirements organically or through teaming arrangements.
Air-Conditioning and Warm Air Heating Equipment and Commercial and Industrial Refrigeration Equipment Manufacturing

POSTED

10 days ago

DEADLINE

in 5 days
View Details

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