Experimental medicine to define mechanisms of gambling disorder: stage one

The Medical Research Council, acting on behalf of UK Research and Innovation, is soliciting proposals for stage one of an experimental medicine initiative to define the mechanisms of gambling disorder. This UK-wide opportunity seeks academically led projects involving living human subjects to investigate causal biological, cognitive, or psychosocial mechanisms. While the primary goal is to address gaps in the understanding of gambling disorder through measurable clinical, behavioral, cognitive, or neurobiological outcomes, projects must demonstrate a clear trajectory toward clinical impact in the prevention or treatment of gambling-related harms, including potential policy changes. The solicitation was posted on October 5, 2026, with a response deadline of April 14, 2027. Evaluation will be based on objective, transparent, and robust criteria, with a specific focus on team cohesion rather than individual applicants and an inclusive approach regarding career stages. Awarded organizations are responsible for obtaining necessary ethical reviews and must adhere to trusted research and innovation principles for any international collaborations. Jaideep Gupte serves as the Senior Responsible Officer for the Research Programme on Gambling, and primary inquiries should be directed to gamblingexpmed@mrc.ukri.org.