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This Sources Sought opportunity from National Aeronautics And Space Administration was posted on February 28, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

Frozen Return of Samples To Earth (FROSTE)

Closed
25-56-PS50Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541714
New
Federal
AJ12--Development/Production - Kidney GEC-Specific AAV Vector
Solicitation # 36C24E27Q0009
The Department of Veterans Affairs is issuing a Sources Sought notice to identify capable vendors for the development and production of a kidney glomerular endothelial cell specific adeno-associated virus AAV vector. This project, funded by a VA ORD Merit award, aims to create a homing peptide enabled vector platform to target the glomerular endothelium to treat kidney injury and disease while reducing off target transduction. The scope of work is divided into three primary tasks: the engineering and incorporation of targeting peptides into the AAV capsid, testing vector binding and internalization in kidney tissue slices, and evaluating the specificity and efficiency of the modified vector through bioluminescence imaging and in vivo biodistribution studies. Qualified contractors must possess extensive onsite resources, including BSL 2 laboratories, specialized DNA and RNA facilities, and advanced instrumentation such as the Agilent Fragment Analyzer and various qPCR platforms. Vendors must demonstrate proven success in animal and human cell vector delivery and maintain full compliance with AAALAC and FELASA health standards. The government requires quarterly reporting, weekly videoconferences, and biannual face to face meetings. All generated data will be subject to Government Purpose Rights, and contractors must adhere to strict federal records management and information security protocols. Interested parties must submit a capability statement, relevant literature, and socio economic status details under NAICS 541714 by November 4, 2026.
Rpo East (36C24E)

POSTED

about 20 hours ago

DEADLINE

in 13 days
NAICS: 541714
New
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Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)
Solicitation # RFA-AI-28-012
The National Institute of Allergy and Infectious Diseases (NIAID) has issued solicitation RFA-AI-28-012 to establish a consortium of Translational Centers Using Microphysiological Systems for Infectious Diseases (TCMID). The primary objective is to refine and validate human tissue models using Microphysiological Systems (MPS) to a level consistent with regulatory qualifications, thereby promoting their adoption by product developers and reducing reliance on laboratory animals. This initiative aligns with NIH and FDA guidance on New Approach Methodologies (NAMs) to accelerate the development of safer medical interventions by capturing human variability and patient-specific characteristics. The program is structured around an Administrative Core, a Qualification Core, and Scientific Cores, with a heavy emphasis on technical readiness, reproducibility, and regulatory acceptance. Key deliverables include the validation of assays for specific endpoints and the submission of regulatory packages. Applicants must be domestic entities, as foreign organizations and foreign subawards are strictly prohibited. Required personnel must possess deep expertise in infectious diseases, MPS platforms, bioinformatics, and FDA submission processes. Applications are due by January 29, 2027, and must be submitted via the NIH ASSIST system or approved institutional system-to-system solutions. Evaluation is based on an overall impact score considering the project's significance, the suitability of the investigators, and the quality of the institutional environment. Mandatory application components include a Data Management and Sharing Plan and a Benchmarks and Timeline PDF not exceeding six pages. Awardees must also adhere to strict cybersecurity incident reporting guidelines, notifying HHS within 48 hours of any discovery.
National Institutes Of Health

POSTED

2 days ago

DEADLINE

in 3 months
NAICS: 541714
New
Grant
Immune Tolerance Network (UM1 Clinical Trial Required)
Solicitation # RFA-AI-28-005
The National Institutes of Health, under the Department of Health and Human Services, is seeking applications through solicitation RFA-AI-28-005 to continue the Immune Tolerance Network (ITN). This cooperative agreement aims to develop tolerogenic therapies for immune-mediated disorders, specifically focusing on autoimmune diseases, allergic diseases and asthma, and the immune-mediated consequences of transplantation. The network operates through four integrated functional areas: Leadership, Clinical Operations, Core Laboratory, and Bioinformatics. Its primary objectives include designing and conducting clinical trials, performing integrated mechanistic studies, and sharing research results. Eligible applicants include small businesses and other for-profit organizations, though non-domestic entities are ineligible. Applications are evaluated based on scientific and technical merit, with a primary focus on significance and the likelihood of exerting a sustained influence on the research field. Key requirements include maintaining active registrations in SAM.gov, eRA Commons, and Grants.gov, as well as adhering to strict cybersecurity incident reporting and human subject protection protocols. The project requires a minimum effort of 3.6 person months per year for the PD/PI and mandates participation in a kick-off meeting in Bethesda, Maryland, and bi-annual steering meetings. Applications must follow specific page limits for the research strategy subsections and include detailed plans for clinical trial implementation, data management, and biorepository services.
National Institutes Of Health

POSTED

2 days ago

DEADLINE

in 3 months

General Info

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

AL, USA

Set-Aside

NONE

Documents

0

No documents available

Documents will appear here when they are available.

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Timeline

1 update
PhaseClosed
Posted

Sources Sought

Notice updated

The notice description changed.

Response Deadline

Deadline has passed

Submission Closed

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Organization & Contact Information

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AgencyNational Aeronautics And Space Administration → NASA Marshall Space Flight Center
Contacts2 people available
OfficeHUNTSVILLE, AL, 35812, USA
Office AddressHUNTSVILLE, AL, 35812, USA
Contacts
Cornelius Edison
Cynthia Hubbard

Full Description

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2/28/2025 Question 1: I was hoping to learn if this is considered a new requirement? If not, would it possible to get the incumbent contractor, contract number, and value? Answer to Question 1: FROSTE is a new requirement. _______________________________________________________________________ NASA/Marshall Space Flight Center (MSFC) is hereby soliciting information from potential sources for the Frozen Return of Samples to Earth (FROSTE) effort. The National Aeronautics and Space Administration (NASA)/MSFC is seeking capability statements from all interested parties. The Government reserves the right to consider all categories of small business set-asides based on responses received. NASA/MSFC has a requirement for maintaining near constant temperatures of samples in cryogenically cold environments where little or no power is available. The latent heat of solidification in insulating materials could be utilized to help maintain sample conditions assuming appropriate materials are identified and available. The purpose of this Request for Information (RFI) is to seek information on companies that can identify and provide candidate materials for such applications. The temperature range of greatest interest is from approximately 70 to 120k. Additional details are noted below. This RFI concerns identification of materials and corresponding fluids that could provide heat transfer and heat storage in cold environments using the latent heat of solidification. Such materials could be utilized for thermal control in lunar and Martian exploration systems. Of particular interest is the identification and development of phase change materials capable of providing thermal consistency and uniformity throughout controlled volumes in cryogenically environments where little to no power is available. Identification of the most appropriate materials for heat storage and transfer in such low temperature environments would enable NASA's technological and hardware developments and inform future NASA procurements. Information regarding the properties, availability, and manufacturability of appropriate materials is requested. Preferred materials would exhibit low toxicity, low flammability, low volatility/vapor pressure, and a broad liquid temperature range. Potential examples of such fluids include hydrofluorocarbons, hydrofluoroolefins, perfluorinated compounds, etc. and mixtures involving these and other compounds. Of particular interest is identifying fluids, whether pure or a mixture, with a broad range between melting and normal boiling points in the liquid range of interest, i.e. from near ambient to near cryogenic temperatures. The specific information desired for a given material with an indication if the information is an estimate, measured, or unknown is as follows: Melting point Normal boiling point Latent Heat of Solidification/Melting Heat of Vaporization Flammability, e.g. flash point, lower explosion or lower flammability limit (LEL/LFL). Toxicity Conductivity of the liquid and solid phases Specific heat of the liquid and solid phases Phase Diagram Solidification behavior, e.g. is it consistent, does it undercool readily, or become glassy or crystalline? Characteristics of the Fluid, e.g. pure or mixture, azeotropic or not, eutectic or not, etc. Identify if the material is readily available or if not then identify the approximate time and other requirements necessary to manufacture the material. No solicitation exists; therefore, do not request a copy of the solicitation. If a solicitation is released, it will be synopsized on SAM.gov. Interested firms are responsible for monitoring this website for the release of any solicitation or synopsis. Interested firms having the required capabilities necessary to meet the above requirement described herein should submit a capability statement of no more than ten (10) pages indicating the ability to perform all aspects of the effort. Statement of Capabilities: Interested parties that have the experience base, expertise, and capabilities necessary to meet or exceed the stated requirements to collaborate with NASA/MSFC regarding materials which can utilize the latent heat of solidification to store and/or absorb heat in cryogenic or near cryogenic environments are invited to submit a capability statement. All responses shall be submitted electronically via email to Cornelius Edison (cornelius.d.edison@nasa.gov) and Cynthia Hubbard (cynthia.a.hubbard@nasa.gov) no later than March 12, 2025, 2:00p.m. CST. Please reference - FROSTE in any response. Phone calls will not be accepted. Submissions should be in Microsoft Word, PowerPoint, or PDF format. Files should not be more than ten (10) pages (no less than 12-point font, except in figure captions) and contain the following information: Name of the submitter and contact information, phone number, email address, and address of institution or firm Academic faculty or business title Cage code/Unique Entity ID Statement of capabilities and qualifications that address the respondent's ability to provide support which meets the requirements specified above Executive summary (1 page maximum) Acceptable files must be able to be opened in commonly readable formats, such as Adobe Acrobat Reader or Microsoft Office Relevant documents Acceptable files must be able to be opened in commonly readable formats, such as Adobe Acrobat Reader or Microsoft Office This synopsis is for information and planning purposes only and is not to be construed as a commitment by the Government nor will the Government pay for information solicited. Respondents will not be notified of the results of the evaluation.

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POSTED

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