Genomic Data Generation Center for the Gabriella Miller Kids First Pediatric Research Program (U24 Clinical Trial Not Allowed)

The National Institutes of Health, under the Department of Health and Human Services, is soliciting applications for the Genomic Data Generation Center for the Gabriella Miller Kids First Pediatric Research Program via solicitation RFA-RM-27-008. This cooperative agreement aims to support the rapid generation of high-quality genomic, transcriptomic, and epigenomic data from human specimens representing pediatric conditions, such as congenital anomalies and childhood cancers. The selected centers will produce raw and derived data, including whole-genome and long-read sequences, RNA expression, and chromatin accessibility data, identifying SNVs, indels, and structural variants. All deliverables, including BAM, CRAM, and VCF files, must be submitted to the Kids First Data Resource Center to facilitate a public-facing, cloud-based resource for the pediatric research community. The program has a total funding commitment of 5 to 6 million dollars per year for a maximum award period of three years, with individual application budgets capped at 3.5 million dollars per year in direct costs. Eligible applicants include higher education institutions, nonprofits, for-profit organizations, and local or federal governments, though non-domestic entities are ineligible. Applications are due by January 8, 2027, with potential start dates beginning in July 2027. Evaluation is based on innovation, specifically the ability to implement new assays within two months, the operational approach, and the institutional environment. Awardees must adhere to strict cybersecurity incident reporting requirements, notifying HHS within 48 hours of any discovery, and comply with rigorous human subject and biosafety protections.