HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
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The National Institutes of Health, under the Department of Health and Human Services, is seeking applications for the HEAL Initiative Whole Joint Health Program, solicitation number PAR-27-045. This phased mechanistic clinical research program aims to identify and validate biological mechanisms driving joint pain and subsequently test non-pharmacologic or multimodal interventions. The initiative focuses on developing safe, non-addictive, and prevention-oriented approaches to chronic pain in alignment with the 2023 HEAL Whole Joint Pain Workshop and the Make America Healthy Again vision. Eligible projects may span up to five years in total duration. Interested parties must submit their responses by the deadline of October 30, 2026. Further inquiries can be directed to the National Institutes of Health via email at nccihderfunding@nih.gov.
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The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.
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