HSLN CMOS Camera System

The project centers on advancing light scattering microscopy techniques to characterize gene delivery nanoparticles used in emerging gene therapies, addressing critical heterogeneity issues that compromise treatment safety and efficacy. Led by the Biosystems and Biomaterials Division within NIST’s Material Measurement Laboratory, the initiative seeks to enable rapid, multi-attribute measurements of individual nanoparticles’ physical properties, accelerating the development and refinement of gene therapies for complex diseases. The effort is tied to the HSLN CMOS Camera System solicitation, issued under NAICS code 334516 by the Department of Commerce, National Institute of Standards and Technology, with a response deadline of August 19, 2026. The work will be performed at NIST’s facility in Gaithersburg, Maryland, and primary technical contact is Rene D. Edwards, supported by Robert Singman. The solicitation is open as a combined opportunity without set-aside classification, targeting innovation in precision measurement systems critical to next-generation medical manufacturing.