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It’s in the R-loops for neurological disorders

Awarded

GA588347Grant

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The project titled It’s in the R-loops for neurological disorders is a federal initiative funded by the National Health and Medical Research Council of the Australian Government. The research focuses on the critical role of the TREX complex in transporting messenger RNAs from the cell nucleus to the cytoplasm, a process essential for protein production and healthy brain development. By investigating how compromised TREX function contributes to neurological disorders, the study aims to develop targeted treatments for individuals with these defects. The research will be conducted in Adelaide, Australia, utilizing a combination of disease-relevant patient cells, brain-organoids, and mouse models. Managed under solicitation number GA588347, the project seeks to bridge the gap between cellular dysfunction and clinical application to improve outcomes for those suffering from TREX-related developmental issues.

General Info

NHMRC funded research in Adelaide studying TREX complex to treat neurological disorders.

Agency

Australian Government → National Health and Medical Research Council (NHMRC)

Contract Value

$1,665,586.8

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Adelaide, SA, 5000, AUS

Set-Aside

NONE

Awardee

Adelaide University

Award Issued Date

10/19/2026, 12:00:00 AM UTC

Documents

0

No documents available

Documents will appear here when they are available.

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Timeline

PhaseAwarded

PostedOct 19

Contract opportunity posted

AwardedOct 19

Contract was awarded

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Organization & Contact Information

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AgencyAustralian Government → National Health and Medical Research Council (NHMRC)

Contacts1 person available

OfficeN/A

Organization / AgencyAustralian Government → National Health and Medical Research Council (NHMRC)

Office AddressN/A

Contacts

NHMRC Research Help Centre

contact@example.gov

Full Description

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Each cell in human body constantly makes thousands of proteins from thousands of messenger RNAs generated in and delivered from the cell nucleus to the cytoplasm by the TREX complex. Compromised TREX function impacts healthy development, specifically of the energy-hungry brain. We will study the importance of TREX in development using sophisticated disease-relevant patient cells, brains-in-a-dish, and a mouse model with an aim to develop treatments for individuals with a defective TREX function

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