Kidney Precision Medicine Project Recruitment Sites (U01 Clinical Trial Not Allowed)

The Kidney Precision Medicine Project Recruitment Sites solicitation seeks applications to establish sites responsible for enrolling participants with acute kidney injury or chronic kidney disease into a longitudinal cohort study, with the goal of performing standardized kidney biopsies as part of a national precision medicine initiative. These recruitment sites will collaborate closely with tissue interrogation sites, the Kidney Tissue Atlas Coordinating Center, and the Central Hub to ensure consistent acquisition, processing, and analysis of kidney tissue samples, contributing to the creation of a comprehensive Kidney Tissue Atlas. This atlas will be used to define novel disease subgroups, pinpoint critical cellular and interstitial components, and uncover therapeutic pathways and targets for future interventions. The program is designed as a clinical research effort that does not permit clinical trials, focusing exclusively on tissue-based discovery and cohort development. Sites must be prepared to execute strict protocol-based biopsy procedures, maintain rigorous data standards, and participate in coordinated multi-center operations under the oversight of the National Institutes of Health. Applications are being accepted through a U01 funding mechanism, with point of contact information provided for inquiries, and the initiative is open to organizations capable of supporting the logistical, ethical, and scientific demands of large-scale kidney tissue collection and longitudinal participant engagement.