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Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

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RFA-DA-28-013Grant

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The National Institute on Drug Abuse is seeking applications for the renewal and expansion of the Collaboratory on Neural Ensembles and Used Substances (NExUS). This collaborative research initiative focuses on decoding how addictive neurobehavioral states and substance use experiences are represented within brain cell populations. The program aims to develop systematic and scalable methods to identify and map neurons responding to addictive substances, ultimately building a comprehensive multimodal database to analyze how specific neural activity patterns relate to intoxication, craving, and dependence. This federal solicitation, identified as RFA-DA-28-013, was posted on October 9, 2026, with a response deadline of February 9, 2027. Managed by the National Institutes of Health, the opportunity specifically excludes clinical trials. Interested parties can find further details through the official grants portal to submit proposals that align with the goal of understanding the neural mechanisms underlying substance use disorders.

General Info

NIDA seeks applications for NExUS to research neural mechanisms of substance use disorders.

Agency

National Institutes Of Health → National Institute On Drug Abuse

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

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Timeline

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Organization & Contact Information

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AgencyNational Institutes Of Health → National Institute On Drug Abuse
ContactsNo contacts available
OfficeUSA
Organization / AgencyNational Institutes Of Health → National Institute On Drug Abuse
Office AddressUSA
ContactsNo contact information available

Full Description

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The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS). NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations. This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.

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