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Preclinical Animal Research - Pulmonary Arterial Hypertension (PAH) Study

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Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract, managed by the Department of Health and Human Services for the NIH Office of the Director, involves conducting preclinical animal research focused on Pulmonary Arterial Hypertension. The project evaluates the therapeutic effects of soluble adenylyl cyclase inhibition on inflammatory vascular remodeling, utilizing wild-type controls and endothelial cell-specific Cav1 knockout murine models. The selected provider must possess specialized technical expertise in murine models of pulmonary hypertension and maintain strict compliance with federal animal welfare standards. The work will be performed in Chicago, Illinois, with the primary objective of delivering comprehensive research data and findings.

General Info

NIH subcontract for preclinical animal research on pulmonary hypertension in Chicago, Illinois.

Agency

Department Of Health And Human Services → National Institute Of Health Nih-OdView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Chicago, IL, 60607, USA

Set-Aside

NONE

Documents

This scope was carved out of 75N98026R00085.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institute Of Health Nih-Od
ContactsNo contacts available
OfficeN/A
Organization / Agency
Department Of Health And Human Services → National Institute Of Health Nih-Od
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Office AddressN/A
ContactsNo contact information available

Full Description

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Performs preclinical animal research for prime contractors on NIH Office of the Director projects. Evaluates therapeutic effects of soluble adenylyl cyclase (sAC) inhibition on inflammatory vascular remodeling using endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine models and wild-type controls. Requires technical capability in murine models of pulmonary hypertension and compliance with federal animal welfare standards. Delivers research data and findings.

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