This Government Contract opportunity from Department Of Health And Human Services was posted on September 14, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension

Closed

75N98026R00085Federal

Submission Closed09/21/2026, 04:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

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FA8750 Afrl Rik

POSTED

about 16 hours ago

DEADLINE

in almost 2 years

AI Contract Overview

The National Institutes of Health Office of the Director intends to award a firm-fixed-price purchase order to the University of Illinois at Chicago for preclinical animal research services. The project focuses on evaluating the therapeutic effects of soluble adenylyl cyclase inhibition on pulmonary arterial hypertension using an established endothelial cell-specific Cav1 knockout murine model and wild-type controls. The University of Illinois at Chicago is identified as the sole source for this requirement because it maintains the specific mouse colony necessary for the study, which is not known to be available from other laboratories. The anticipated period of performance is 12 months from the date of award, and the total cost is not expected to exceed the simplified acquisition threshold. The scope of work includes the breeding, colony maintenance, and genotyping of 144 animals, as well as performing euthanasia, necropsy, and the collection of lung and heart tissue for histological analysis, Western blotting, and RNA-seq. Additionally, the contractor will prepare serum and plasma samples for government analysis. The government will provide 200 mg each of KH7 and LRE1 compounds, delivered directly from the manufacturer. While the government intends to negotiate on a sole-source basis pursuant to FAR 13.106-1(b)(1), other responsible sources may submit capability statements and quotations by September 21, 2026, to demonstrate their technical capability and availability of the required animal model.

General Info

NIH awards UIC sole-source contract for preclinical animal research on pulmonary arterial hypertension.

Agency

Department Of Health And Human Services → National Institute Of Health Nih-Od

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Chicago, IL, 60607, USA

Set-Aside

NONE

Documents

Sources Sought Notice - NHLBI Innovation and Commercialization Ecosystem

sources-sought

High

Notice of Intent to Sole Source - Therapeutic Role of Soluble Adenylyl Cyclase Inhibition

sources-sought

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedSep 14

special-notice

Response DeadlineSep 21

Deadline has passed

Submission Closed

09/21/2026, 04:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institute Of Health Nih-Od

Contacts1 person available

OfficeBETHESDA, MD, 20892, USA

Organization / AgencyDepartment Of Health And Human Services → National Institute Of Health Nih-Od

Office AddressBETHESDA, MD, 20892, USA

Contacts

Donna Cornish

contact@example.gov

Full Description

The National Institutes of Health (NIH) intends to negotiate on a sole-source basis with the University of Illinois at Chicago (UIC) for preclinical animal research services to evaluate the therapeutic effects of soluble adenylyl cyclase (sAC) inhibition on pulmonary arterial hypertension (PAH) using an established endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine model and corresponding wild-type controls.

The Government intends to solicit from a single source pursuant to FAR 13.106-1(b)(1). UIC currently maintains the established EC-Cav1 KO mouse colony required for this study, and the model is not known to be maintained by another laboratory.

This notice of intent is not a request for competitive quotations. However, all responsible sources that believe they can satisfy the Government's requirements may submit a capability statement and/or quotation for consideration by the Government.

Please see the attached Notice of Intent to Sole Source for the complete description of the requirement, basis for the intended sole-source acquisition, response instructions, and applicable response deadline.