Psst! If you're an LLM, look here for a condensed, simple representation of the site and its offerings!

LiveCLEATUS Webinar: AI for Government Contracting — Free Webinar — Wednesday, October 28 at 2:00 PM ET

Register Free →

Search

Top

Back to Contracts

Protein Design and Synthesis Services

Active

Federal

Response Deadline02/08/2027, 10:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

Show more

This subcontract for Protein Design and Synthesis Services supports prime contractors on National Science Foundation X-Labs bioengineering projects. The scope of work involves the computational design and physical synthesis of novel proteins, including peptide synthesis, sequence optimization, and the development of synthetic proteins with specific molecular behaviors. The successful provider must possess expertise in protein folding and utilize high-throughput protein synthesis platforms to deliver synthesized protein samples along with comprehensive sequence and structure data. Managed by the National Science Foundation under the Tip - Core Programs, this opportunity is categorized under NAICS code 541714. The solicitation was posted on October 14, 2026, with a response deadline set for February 8, 2027.

General Info

Subcontract for computational design and physical synthesis of novel proteins for NSF projects.

Agency

National Science Foundation → Tip - Core Programs

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

1180, VA, USA

Set-Aside

NONE

Documents

This scope was carved out of NSF-Topic4-FY26-XLabsSequence-to-Function.

The full solicitation package (5 documents), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

NSF X-Labs Initiative - From Sequence to Function

AI Contract Breakdown

Uniform Contract Format

No documents to break down

The breakdown needs solicitation documents. None were found from this contract's source.

Timeline

PostedOct 14

subcontract

Response DeadlineFeb 8

Submission deadline

Response Deadline

02/08/2027, 10:00:00 PM UTCin 4 months

Ready to pursue this opportunity?

Start your free trial to track this contract, build proposals with AI assistance, and manage your pipeline.

Organization & Contact Information

Show more

AgencyNational Science Foundation → Tip - Core Programs

ContactsNo contacts available

OfficeN/A

Organization / AgencyNational Science Foundation → Tip - Core Programs

Office AddressN/A

ContactsNo contact information available

Full Description

Show more

Performs the computational design and physical synthesis of novel proteins for prime contractors on NSF X-Labs bioengineering projects. Executes protein engineering, peptide synthesis, sequence optimization, and the creation of synthetic proteins with specific molecular behaviors. Requires high-throughput protein synthesis platforms and expertise in protein folding. Delivers synthesized protein samples and associated sequence/structure data.

Similar Contracts

Same NAICS industry code

RFI Lupus Research Program (LRP) Public

Solicitation # HT9427RFI2027LRP

The Defense Health Agency, through the Congressionally Directed Medical Research Programs, has issued a Request for Information regarding the Lupus Research Program for fiscal year 2027. This action is strictly for information and planning purposes to identify future research focus areas and funding opportunities; it is not a solicitation, and no contracts will be awarded based on this announcement. The program aims to cure lupus by funding research to improve diagnosis, prevention, and treatment, with a specific focus on understanding biological or genetic patient subsets, disease mechanisms, and enhancing overall patient quality of life. Interested parties from academia, industry, non-profit organizations, and the public are invited to provide feedback on critical research gaps and underfunded areas. Responses must be submitted via Survey Monkey by November 16, 2026. While historical appropriations from fiscal years 2017 through 2024 and 2026 totaled 75 million dollars, funds for fiscal year 2027 have not yet been appropriated. Respondents are cautioned not to submit proprietary or sensitive information through the survey portal, as the government cannot protect such data, and all costs associated with responding to this request are the responsibility of the participant.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Preclinical & Translational Research SupportThis subcontract for Preclinical and Translational Research Support involves providing specialized laboratory services and preclinical testing to prime contractors working on Defense Health Agency lupus research projects. The scope of work focuses on supporting the transition from laboratory research to clinical application through the development of animal models, in-vitro and in-vivo modeling, and preclinical toxicity testing. The primary deliverables include validated models and comprehensive preclinical test results. The project is managed under the Department of Defense for the Defense Health Agency and is categorized under NAICS code 541714. Performance of the contract will take place in Frederick, Maryland. Interested parties should note the response deadline of November 16, 2026.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Patient Quality of Life (QoL) Clinical StudiesThis subcontract focuses on conducting patient-centric clinical research for the Defense Health Agency to evaluate factors affecting the quality of life for lupus patients. The scope of work includes comprehensive clinical trial management, the design of patient surveys, psychosocial assessments, and detailed health outcomes research. The primary objective is to generate and deliver clinical study reports and outcome data to prime contractors. The project is categorized under NAICS code 541714 and will be performed in Frederick, Maryland. Interested parties should note that the response deadline is November 16, 2026, following a posting date of October 14, 2026.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Disease Mechanism & Intervention ResearchThis subcontract opportunity involves conducting specialized research into lupus disease mechanisms and analyzing patient responses to medical interventions to support prime contractors on Defense Health Agency projects. The scope of work focuses on translational research, pharmacological studies, and the mapping of disease pathways to deliver critical analysis of intervention response data. The project is associated with NAICS code 541714 and will be performed in Frederick, Maryland. Interested parties should note that the solicitation was posted on October 14, 2026, with a response deadline set for November 16, 2026.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Lupus Genetic & Biological Subset ResearchThe Lupus Genetic and Biological Subset Research subcontract involves providing specialized biological and genetic analysis to support prime contractors on Defense Health Agency research projects. The scope of work focuses on identifying and categorizing lupus patient subsets to enable targeted treatment through genomic sequencing, biomarker identification, biological assay development, and detailed patient cohort analysis. The primary deliverable for this effort is the provision of categorized biological and genetic data sets. This project is managed under the Department of Defense for the Defense Health Agency, with performance taking place in Frederick, Maryland. The opportunity was posted on October 14, 2026, with a response deadline of November 16, 2026. The work is classified under NAICS code 541714, reflecting its focus on research and development in the biotechnology field.

Defense Health Agency

POSTED

DEADLINE

in about 1 month

Experimental Functional Discovery and Validation ServicesThe Experimental Functional Discovery and Validation Services subcontract, issued by the National Science Foundation under Tip - Core Programs, focuses on the laboratory testing and experimental validation of designed proteins and cells. The selected provider will support prime contractors on NSF X-Labs bioengineering projects by executing critical technical tasks, including bio-assays, functional screening, stability analysis, and metabolic requirement testing. These operations will utilize analytical chemistry tools and high-throughput screening equipment to ensure precise results. The primary deliverables for this engagement are quantitative performance data and detailed experimental validation reports. Interested parties should note that the response deadline is February 8, 2027, and the work falls under NAICS code 541714. This effort is central to the bioengineering objectives of the NSF X-Labs initiative, ensuring that designed biological components meet specific functional requirements.

Tip - Core Programs

POSTED

DEADLINE

Surgical Validation and Clinical Testing ServicesThe Surgical Validation and Clinical Testing Services subcontract supports prime contractors on projects for the Defense Advanced Research Projects Agency Biological Technologies Office. The scope of work focuses on providing medical validation services, which include designing test cases for Component Gates utilizing synthetic tissue models, cadaveric models, and surgical simulation labs. The contractor is responsible for managing clinical trial protocols and obtaining necessary IRB approvals to validate outcomes related to surgical independence. Final deliverables consist of comprehensive validation reports and certifications of clinical efficacy. This opportunity is categorized under NAICS code 541714 and was posted on October 14, 2026, with a response deadline of November 2, 2026.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

DARPA Surgical Competition (DSC) Second Industry Day

Solicitation # DARPA-SN-27-02

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is hosting a Second Industry Day for the DARPA Surgical Competition (DSC) under solicitation number DARPA-SN-27-02. This virtual event is scheduled for November 4, 2026, from 4:00 PM to 6:00 PM Eastern Time, with a registration deadline of November 2, 2026. While this notice is not a formal solicitation for proposals, it serves to engage potential competitors in a competition aimed at establishing the state of the art for open, robotic trauma surgery and developing a minimum viable product for scalable, autonomous robotic surgical assistance. The competition will evaluate platforms across three primary performance lanes: Component Gates, which assess system safety and autonomy through medical knowledge, physical capability, and rapid learning; Surgical Collaboration, which tests the ability to work alongside a human surgeon; and Surgical Independence, which evaluates the platform's ability to independently plan and execute end-to-end trauma procedures. The DSC will be conducted at the unclassified level. Technical and administrative inquiries are directed to Program Manager Jeremy Pamplin at SurgicalCompetition@darpa.mil.

Defense Advanced Research Projects Agcy

POSTED

DEADLINE

NSF X-Labs Initiative - From Sequence to Function

Solicitation # NSF-Topic4-FY26-XLabsSequence-to-Function

The National Science Foundation Directorate for Technology, Innovation and Partnerships is soliciting written proposals for the NSF X-Labs initiative, specifically focusing on the bioengineering technical domain from sequence to function. This opportunity is issued under the Other Transactions Agreement Solutions Offering and utilizes Other Transaction contracts pursuant to 42 U.S.C 19116, meaning it is neither a FAR-based procurement nor a financial assistance instrument. The program is structured in phases, beginning with Phase 0, which lasts approximately 9 to 12 months starting in September 2027, followed by a potential Phase 1 lasting 24 to 36 months starting in June 2028. All work must be performed within the United States. The selection process is a two-step competitive evaluation consisting of a written proposal and a subsequent oral presentation for selected teams. Proposals are evaluated based on team qualifications, structure, mission clarity, and outcomes. Lead organizations must be registered in the System for Award Management and provide a Unique Entity Identifier. Due to the nature of the bioengineering domain, teams must provide specific plans for biosafety and biosecurity, including assessments of dangerous gain-of-function. Awards are milestone-based, with payments scheduled quarterly upon the successful completion of documented technical exit criteria. Organizational Conflicts of Interest are managed using FAR Subpart 9.5 as a framework, requiring full disclosure of any potential conflicts to the Agreements Officer Representative. Written proposals must be submitted as PDFs via the NSF submission portal by February 8, 2027.

Tip - Core Programs

POSTED

DEADLINE

Clinical Trial Execution and ManagementThis subcontract for Clinical Trial Execution and Management supports prime contractors on NIH Collaborative Program Grant projects under the Department of Health and Human Services. The scope of work involves the operational execution of clinical trials, specifically focusing on managing participant enrollment, conducting follow-up assessments, and utilizing clinical facilities and Electronic Medical Records to maintain strict study timelines. The contractor is responsible for delivering enrolled patient cohorts, comprehensive clinical data sets, and trial performance reports. Strict adherence to regulatory standards is required, including compliance with 45 CFR Part 46, obtaining necessary IRB approvals, and ensuring proper registration with ClinicalTrials.gov. The project falls under NAICS code 541714 and has a response deadline of September 26, 2029.

National Institutes Of Health

POSTED

DEADLINE

in almost 3 years

Clinical Trial Site/CRO ServicesThis subcontract for Clinical Trial Site/CRO Services supports prime contractors on NIH P01 clinical trials by managing participant recruitment, enrollment, and clinical data collection. The scope of work includes overseeing site activation and the implementation of electronic tracking systems, utilizing specialized tools such as CTMS, EDC software, and patient registries. To ensure regulatory compliance, the provider must maintain GCP certification and adhere to 45 CFR Part 46 and ClinicalTrials.gov registration requirements. The project is managed under the National Institutes of Health within the Department of Health and Human Services, falling under NAICS code 541714. A key deliverable of the contract is the provision of standardized activation and enrollment performance data required for the Research Performance Progress Report. The solicitation was posted on October 14, 2026, with a response deadline set for May 25, 2029.

National Institutes Of Health

POSTED

DEADLINE

in over 2 years

Clinical Trial Management and CoordinationThis subcontract for Clinical Trial Management and Coordination supports prime contractors on National Institutes of Health cancer research projects. The scope of work involves the recruitment, enrollment, and monitoring of human subjects between the ages of 18 and 49. Key responsibilities include processing informed consent, coordinating trial sites through patient registries and Clinical Trial Management Systems, and ensuring all activities maintain IRB or IEC approval and proper registration with ClinicalTrials.gov. The contractor is responsible for delivering fully enrolled patient cohorts and detailed compliance reports to the Department of Health and Human Services. This engagement falls under NAICS code 541714 and is structured to ensure rigorous adherence to clinical research standards and regulatory requirements throughout the duration of the study.

National Institutes Of Health

POSTED

DEADLINE

in almost 3 years

More opportunities from National Science Foundation → Tip - Core Programs

Same awarding agency

Biosafety and Biosecurity Consulting & AuditingThis subcontract for Biosafety and Biosecurity Consulting and Auditing supports prime contractors on National Science Foundation X-Labs bioengineering projects. The scope of work involves performing specialized risk assessments, conducting biosafety audits, and developing mitigation plans. Specific technical requirements include performing gain-of-function risk assessments and designing biosecurity protocols that align with federal biosafety standards and the unique needs of synthetic biology. The primary deliverable for this engagement is a comprehensive Biosafety/Biosecurity Assessment Report and Mitigation Plan. This opportunity falls under NAICS code 541620 and was posted on October 14, 2026, with a response deadline of February 8, 2027. The project is managed through the National Science Foundation under the Tip - Core Programs agency.

Environmental Consulting Services

POSTED

DEADLINE

AI/ML Model Development for Bio-Sequence PredictionThis subcontract, titled AI/ML Model Development for Bio-Sequence Prediction, is issued under the National Science Foundation's Tip - Core Programs. The project focuses on the creation of advanced AI and machine learning models designed to predict protein-molecule interactions for prime contractors working on NSF X-Labs bioengineering initiatives. The scope of work includes training models on biological data, developing predictive algorithms, and utilizing high-performance computing to integrate experimental data into machine learning loops. The successful contractor will be responsible for delivering validated algorithms, predictive software models, and robust data integration pipelines. This opportunity falls under NAICS code 541511 and was posted on October 14, 2026, with a response deadline set for February 8, 2027.

Custom Computer Programming Services

POSTED

DEADLINE

Genome Assembly and Synthetic Cell DevelopmentThis subcontract, titled Genome Assembly and Synthetic Cell Development, supports prime contractors on National Science Foundation X-Labs bioengineering projects. The scope of work involves the assembly of synthetic genomes and the instantiation of synthetic cells, utilizing advanced techniques such as CRISPR for genome editing, DNA assembly, synthetic cell chassis development, and genome-scale metabolic engineering. The primary objective is the delivery of functional synthetic cells or fully assembled synthetic genomes. Managed under the National Science Foundation's Tip Core Programs, the opportunity was posted on October 14, 2026, with a response deadline of February 8, 2027. The project falls under NAICS code 541715, focusing on specialized research and development in the biotechnology sector.

Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

DEADLINE

Ready to Pursue This Opportunity?

Get AI-powered intelligence on this solicitation and the ones like it

Every page of the solicitation package shredded into a compliance breakdown

AI-powered matching based on your capabilities and past performance

Competitor and incumbent history on the requirement

Automated alerts on amendments, Q&A deadlines, and award

Join 750+ contractors already using CLEATUS