Providence Health Care.

This is a NOTICE OF INTENT TO AWARD A SOLE SOURCE CONTRACT (as prescribed in FAR 6.302-1(a)(2). This notice is for Clinical course of chronic kidney disease with National Death Index linkage. The Centers for Disease Control and Prevention intends to solicit and award a contract on a sole sources basis to PROVIDENCE HEALTH & SERVICES-WASHINGTON Providence Health Care. National survey data indicate that 15% of the US adult population has chronic kidney disease (CKD), representing 37 million persons affected by the disease (1). Therefore, it is critical to identify persons at risk for CKD or in the early stages of the disease, to effectively implement proven preventive and therapeutic strategies, and reduce the burden of CKD. Analyses of health care data allow observation of real-world diagnostic and therapeutic practice patterns and clinical course of these patients, offering valuable insight into determinants of clinically meaningful outcomes such as kidney failure requiring dialysis or transplantation and premature death. Patients, providers, and policymakers are in need of enhanced understanding of CKD trajectories, risk prognostication, and opportunities to test interventions designed to improve outcomes. Contemporary data for CKD progression is particularly timely and important with the emergence of highly effective new therapies for prevention and treatment. This project is related and complementing a previous project with Providence Health Care (PHC) that is capitalizing on a comprehensive electronic health records (EHR) registry, the CURE-CKD - Center for Kidney Disease Research, Education and Hope for Chronic Kidney Disease. Using inpatient and outpatient encounters, procedures, laboratory and pharmacy records from PHC and the University of California Los Angeles (UCLA), this large EHR-based registry includes to date ~3 million people across Washington, Alaska, Idaho, Oregon, Montana, and California with CKD, diabetes, prediabetes, and/or hypertension from the years 2006-2022. The CURE-CKD registry was created and is being continuously updated by Prof. Katherine Tuttle, MD, FASN, FACP, FNKF, (Katherine.Tuttle@providence.org) and her team at PHC and the University of Washington, Spokane and Seattle, WA. Dr. Tuttle is Professor of Medicine in the Nephrology Division at the University of Washington, the Executive Director for Research at PHC, and the Regional Co-Principal Investigator for the Institute of Translational Health Sciences (Clinical and Translational Science Award at the University of Washington). Her team includes biostatisticians, epidemiologists, and geocoding experts. They are the only ones who can access, use and update the CURE-CKD registry. As documented in - Advancing American Kidney Health, a goal of the Department of Health and Human Services is to reduce the risk of kidney failure through public health surveillance capabilities and research to improve identification of populations at risk and those in early stages of kidney disease (https://www.hhs.gov/about/news/2019/07/10/hhs-launches-president-trump-advancing-american-kidney-health-initiative.html). The work from this project will permit the CDC-sponsored Kidney Disease Surveillance System to determine modern-day risks of mortality, ESRD, and CVD among patients with, and at-risk for, CKD using a unique and curated real-world database from two large healthcare systems in the United States. These analyses will be used to develop publications for peer-reviewed reports and will be available on the CDC CKD Surveillance website. Understanding of Requirements and Proposed Technical Approach CURE-CKD is a model dataset for this rigorous investigation given the large sample of curated EHR data from youth and adults, analytic-ready dataset, longitudinal clinical covariates and outcomes, annual updates, and collaboration with the Centers for Disease Control and Prevention. Independent and synergistic relationships will be determined for traditional and non-traditional CKD risk factors, including with longitudinal outcomes: eGFR decline; mortality, kidney failure, and cardiovascular outcomes. The data will also be used to delineate additive and multiplicative interactions between traditional and non-traditional (e.g. access to health care, environmental exposures, socioeconomic status, and awareness) risk factors to predict CKD progression and mortality. Linkages between the CURE-CKD registry and the USRDS, National Death Index, Social Security Death Index, and state death registries have been or will be established to verify occurrences of kidney failure, deaths, and causes of death. The period of performance is September 1, 2023-August 31, 2024 The NAICS code for this action is NAICS 611310 -- Colleges, Universities, and Professional Schools Interested sources may identify their interest and capability to respond to the requirement or submit a proposal to jmo4@cdc.gov no later than 7 calendar days after release of this synopsis. Proposals received within 7 days after publication will be considered by the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement.