R -- The Induction and Isolation of microsomal enzymes.
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The CDC plans to award a sole source purchase order to the University of Georgia to conduct a project focused on inducing and isolating microsomal enzymes in adult female and immature rodents after exposure to volatile organic compounds (VOCs). The objective is to use the resulting in vivo data to validate computer-based physiologically based pharmacokinetic (PBPK) modeling parameters such as Km and Vmax for different substrates across age groups ranging from birth through sexual maturation. This procurement is justified under FAR part 6.302-1 as the University of Georgia is identified as the only entity with the necessary expertise to carry out this specialized work. No competitive solicitation is being issued, but the CDC invites other firms that believe they can perform the required services to notify the Contracting Officer in writing within 15 days of the synopsis publication. The government will use any responses received solely to decide whether to proceed with a competitive process, and the final decision rests entirely with the government. Questions or inquiries about the project can be directed to Christine Dorsey via email or fax as provided.
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