Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

The National Institutes of Health, through the Office of Research Infrastructure Programs, is soliciting R24 grant applications under RFA-OD-25-010 to support the development, characterization, or improvement of research models of human health and diseases. This includes biology-based new approach methodologies and related biological materials. To be eligible, proposed resources must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers and must evaluate diseases and processes that impact multiple organ systems. Projects focusing strictly on a specific disease or a select area of research without broad NIH-wide impact will not be accepted. Clinical trials are not allowed under this funding opportunity. The NIH intends to commit 5,000,000 dollars per fiscal year from 2026 through 2029, with a maximum project duration of four years. Eligible applicants include small businesses, other for-profit organizations, and local, state, or federal government entities, though foreign organizations are not eligible to apply. Applications are evaluated based on scientific and technical merit through a peer review system, focusing on the investigators and the potential for the project to exert a sustained, powerful influence on the research field. Required registrations include an active SAM account with a Unique Entity Identifier, a CAGE or NCAGE code, and eRA Commons and Grants.gov accounts. Submission deadlines occur periodically from January 2026 through September 2028.