This Sources Sought opportunity from Department Of Health And Human Services was posted on April 20, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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RRPV BoNT-NMJ

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SSN-BARDA-04202026Federal

Submission Closed05/11/2026, 05:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

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9 days ago

DEADLINE

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AI Contract Overview

The contract seeks innovative approaches to advance the evaluation of botulinum neurotoxins (BoNT) by transitioning from traditional mouse-based bioassays to human-relevant in vitro systems. Specifically, it focuses on developing neuromuscular junction (NMJ) micro-physiological platforms that can accurately measure BoNT potency and assess the effectiveness of medical countermeasures while reducing animal testing. These in vitro systems should offer mechanistic insight into the toxin’s activity, including the ability to demonstrate recovery of neuronal signaling, which is critical for evaluating therapeutic interventions. The initiative is led by BARDA under the Department of Health and Human Services and is aimed at exploring whether these alternative platforms can eventually validate and potentially replace mouse potency and neutralization assays commonly used today. The solicitation, numbered SSN-BARDA-04202026 and posted in April 2026, encourages responses by mid-May 2026 from entities capable of advancing this technology. The effort aligns with growing ethical and regulatory interests in minimizing animal use in testing while enhancing the biological relevance and accuracy of BoNT assessment methods.

General Info

Develop human-relevant in vitro NMJ platforms to replace mouse BoNT assays for potency testing.

Agency

Department Of Health And Human Services → Barda - Aspr / Daappo / Barda DcmaView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Washington, DC, USA

Set-Aside

NONE

Documents

(1)

RRPV_RFI_BoNT-NMJ+RFI.pdf

PDF

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedApr 20

Sources Sought

Response DeadlineMay 11

Deadline has passed

Submission Closed

05/11/2026, 05:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

Contacts2 people available

OfficeWASHINGTON, DC, 20515, USA

Organization / Agency

Department Of Health And Human Services → Barda - Aspr / Daappo / Barda Dcma

View Agency Profile

Office AddressWASHINGTON, DC, 20515, USA

Contacts

Kathy Garee

contact@example.gov

Yifan Yang

contact@example.gov

Full Description

Botulinum neurotoxins (BoNT/A–G) inhibit acetylcholine release at the neuromuscular junction through cleavage of SNARE proteins (e.g., SNAP-25, VAMP, syntaxin). Currently, BoNT characterization, including toxin potency and neutralization by medical countermeasures, is measured using mouse-based bioassays, primarily the Mouse Potency Assay (MPA) and Mouse Neutralization Assay (MNA), respectively.

There is increasing scientific, ethical, and regulatory interest in transitioning to human-relevant in vitro systems that can provide mechanistic insight while reducing reliance on animal testing. NMJ micro-physiological systems may provide a biologically relevant platform capable of measuring BoNT potency and evaluating countermeasure efficacy.

BARDA is interested in understanding whether NMJ-based in vitro platforms could support future development of validated assays capable of reducing and potentially replacing reliance on mouse bioassays for BoNT potency and neutralization measurements, with specific interest in systems that can show recovery of neuronal signaling and thereby be appropriate for medical countermeasures evaluation.