This Government Contract opportunity from Department Of Health And Human Services was posted on May 14, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Single-Domain Antibody Discovery and Phage Display Screening

Closed

Federal

Submission Closed05/24/2026, 01:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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AI Contract Overview

This contract involves conducting phage display screening to identify single-domain VHH nanobodies that specifically bind to the extracellular domain of the human Calcium-Sensing Receptor (CaSR). The process includes both positive selection for target binding and negative selection to eliminate candidates that interact with off-target G protein-coupled receptors (GPCRs), ensuring specificity of the identified nanobodies. Issued as a subcontract with a total small business set-aside under the Small Business Administration guidelines, the contract is managed by the National Institutes of Health within the Department of Health and Human Services. The work is to be performed in Bethesda, Maryland, with a response deadline set for May 24, 2026. The contract falls under the NAICS code 541715, which pertains to research and development in the physical, engineering, and life sciences field.

General Info

Phage display screening to identify specific VHH nanobodies binding human CaSR, NIH subcontract.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Bethesda, MD, 20817, USA

Set-Aside

SBA

Documents

This scope was carved out of 75N98026Q00360.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Single Domain Antibody Development Service

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Timeline

PhaseClosed

PostedMay 14

subcontract

Response DeadlineMay 24

Deadline has passed

Submission Closed

05/24/2026, 01:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao

ContactsNo contacts available

OfficeN/A

Organization / Agency

Department Of Health And Human Services → National Institutes Of Health Olao

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Office AddressN/A

ContactsNo contact information available

Full Description

Conduct phage display screening to identify VHH nanobodies binding to the human Calcium-Sensing Receptor (CaSR) ECD, including positive and negative selection against off-target GPCRs.