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Supply of EC-Cav1 KO Murine Models

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Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract with the National Institute of Health NIH-OD involves the supply and delivery of endothelial cell-specific Cav1 knockout murine models and wild-type control mice to support prime contractors on Office of the Director projects. The provider is responsible for maintaining the genetic integrity and health of the genetically modified mouse colonies and must provide proof of availability for the specific EC-Cav1 KO model. The agreement requires strict compliance with animal transport regulations for the delivery of the specified number of mice to a research facility located in Chicago, Illinois. This procurement falls under NAICS code 335999 and was posted on September 13, 2026, with a response deadline of September 21, 2026.

General Info

Supply and delivery of EC-Cav1 KO and wild-type mice to NIH-OD in Chicago.

Agency

Department Of Health And Human Services → National Institute Of Health Nih-OdView Agency

NAICS

335999 - All Other Miscellaneous Electrical Equipment and Component ManufacturingView NAICS

Place of Performance

Chicago, IL, 60607, USA

Set-Aside

NONE

Documents

This scope was carved out of 75N98026R00085.

The full solicitation package (1 document), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension

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Timeline

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institute Of Health Nih-Od
ContactsNo contacts available
OfficeN/A
Organization / Agency
Department Of Health And Human Services → National Institute Of Health Nih-Od
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Office AddressN/A
ContactsNo contact information available

Full Description

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Supplies endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine models and wild-type control mice for prime contractors on NIH Office of the Director projects. Provides and delivers genetically modified mouse colonies while ensuring genetic integrity and health. Requires proof of availability of the specific EC-Cav1 KO model and compliance with animal transport regulations. Delivers the required number of mice to the research facility.

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NAICS: 541715
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Federal
The Therapeutic Role of Soluble Adenylyl Cyclase Inhibition in Ameliorating Inflammatory Vascular Remodeling in Pulmonary Arterial Hypertension
Solicitation # 75N98026R00085
The National Institutes of Health Office of the Director intends to award a firm-fixed-price purchase order to the University of Illinois at Chicago for preclinical animal research services. The project focuses on evaluating the therapeutic effects of soluble adenylyl cyclase inhibition on pulmonary arterial hypertension using an established endothelial cell-specific Cav1 knockout murine model and wild-type controls. The government is pursuing a sole-source acquisition under FAR 13.106-1(b)(1) because the University of Illinois at Chicago maintains the specific mouse colony required for the study, which is not known to be available from other laboratories. The scope of work involves 144 animals subjected to normoxia or chronic hypoxia and treated with sAC inhibitors KH7 or LRE1, both of which will be provided by the government. Required services include animal breeding, colony maintenance, genotyping, implantation of subcutaneous osmotic pumps, echocardiography, and right-heart catheterization. The contractor will also be responsible for necropsy and the preparation of lung and heart tissue for histological analysis, Western blotting, and RNA-seq. The anticipated period of performance is 12 months from the date of award, and the total value is not expected to exceed the simplified acquisition threshold. While the government intends to negotiate with a single source, responsible parties may submit capability statements and quotations by September 21, 2026.
Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

POSTED

1 day ago

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in 7 days
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