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The scope of this work is to provide EPA with assay platforms that: (1) utilize rudimentary �organoids� and microscale tissues built from human pluripotent stem cell (iPSC) lines; (2) build microflui…

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The Environmental Protection Agency is seeking assay platforms designed to advance toxicity testing through the use of human pluripotent stem cell lines. The primary objective is the development of rudimentary organoids and microscale tissues, integrated into microfluidic tissue chips. These chips must support both single and multi-organ configurations to facilitate long-term culture and sophisticated biological modeling. The scope of work requires the execution of in vitro toxicity studies using these novel platforms. These studies must be capable of producing measurable outcomes regarding metabolic capacity, biophysical mechanics, and cellular dynamics. This initiative aims to enhance the agency's ability to assess chemical toxicity using high-fidelity, human-based synthetic tissue models.

General Info

EPA seeks human stem cell organoid chips for advanced in vitro toxicity testing.

Agency

Environmental Protection Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

0

No documents available

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Timeline

PostedJan 1

forecast

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Organization & Contact Information

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AgencyEnvironmental Protection Agency

ContactsNo contacts available

OfficeN/A

Organization / AgencyEnvironmental Protection Agency

Office AddressN/A

ContactsNo contact information available

Full Description

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The scope of this work is to provide EPA with assay platforms that: (1) utilize rudimentary �organoids� and microscale tissues built from human pluripotent stem cell (iPSC) lines; (2) build microfluidic tissue chips that can include single and multi-organ configurations for long-term culture; and (3) run in vitro toxicity studies on these novel platforms in which cellular dynamics, biophysical mechanics, and metabolic capacity are measureable outcomes.

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