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--The US Army's Contracting Division is posting the following synopsis expressing the study of the Effects of Calorie Restriction on Adipokine Signaling in regulation of Growth Hormone Release with Penn State University.

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USA-SNOTE-080110-004Federal

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AI Contract Overview

The U.S. Army's Natick Contracting Division plans to award a purchase order to Penn State University for a research study examining the effects of calorie restriction on adipokine signaling and its role in regulating growth hormone release using mouse models. This study aims to uncover the mechanisms controlling brain cell populations' response to changes in adipokine expression following calorie restriction, as well as to investigate the neuroendocrine responses to short-term calorie restriction. The research is conducted in support of the Military Performance Division at the U.S. Army Research Institute of Environmental Medicine, emphasizing its relevance to military personnel, particularly soldiers engaged in special operations. Penn State was selected due to its established heterogeneous mouse model that better reflects human population diversity, its expertise and resources to perform specialized, complex techniques required for this study, and its existing collaboration with a recognized pituitary gland expert, Dr. We Hymer. The U.S. Army lacks the necessary equipment and labor resources to carry out certain aspects of this project internally. The research promises valuable insights with significant military applications, particularly regarding growth hormone regulation in response to calorie restriction. The opportunity for inquiries about this acquisition is directed to Mr. Nate Jordan at the Natick Contracting Division, with the synopsis expiring on January 14, 2008.

General Info

U.S. Army contracts Penn State to study calorie restriction effects on growth hormone using mice.

Agency

Department Of Defense → W6QK Acc-Apg Natick

NAICS

611310 - Colleges, Universities, and Professional Schools

Place of Performance

Set-Aside

NONE

Documents

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Timeline

PostedJan 10

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Organization & Contact Information

AgencyDepartment Of Defense → W6QK Acc-Apg Natick

ContactsNo contacts available

OfficeNATICK, MA, 01760-5011, USA

Organization / AgencyDepartment Of Defense → W6QK Acc-Apg Natick

Office AddressNATICK, MA, 01760-5011, USA

ContactsNo contact information available

Full Description

Under the authority of FAR 6.302-1, the U.S. Army, REDCOM, Natick Contracting Division, Kansas Street, Natick, MA on behalf of the United States Army Soldier System Center, Natick, MA intends to negotiate and award a purchase order to Penn State Un iversity for a study invloving the Effects of Calorie Restriction on Adipokine Signaling in regulation of Growth Hormone Release to be conducted with mice subjects. The purpose of this study is to (1) determine the mechanism(s) controlling the function of distinct cellular populations within the brain in response to alterations in adipokine expression following CR and (2) to explore the neuroendocrine responses to short-term CR. This research is in support of the Military Performance Division at the US Army Research Institute of Enviornmental Medicine (USARIEM). The subject matter experts (SME) at Penn State are being contracted for the work on this protocol for the following reasons: (1) Penn State has established a heterogeneous mouse model within thei r barrier facility, which more accurately represents the diversity in the human population (2) SMEs at Penn State have extensive knowledge and resources necessary for the critical techniques used to complete this investigation quickly and efficiently. < BR>(3) USARIEM does not have the necessary equipment to perform some of the more expensive and laborious techniques necessary for completion of this project. (4) Penn State has a long-standing consulting relationship with Dr. We Hymer from Alpha Two Con sulting. He is a renowned expert in pituitary gland function. The potential information gained from Dr. Hymers investigation of the pituitary gland responses to CR has significant military relevance to Soldiers during special operations. (5) The SMEs have extensive experience and expertise associated with CR. Questions concerning this acquisition may be addressed to the above address, Attention: Mr. Nate Jordan (AMSRD-ACC-NS) or by e-mail at contact@example.gov. This synopsis expires 14 Jan uary 2008 at 10:00 AM ET.