Therapeutic Set and Setting Protocol Development

The contract seeks the development of a comprehensive therapeutic set and setting protocol for the administration of ibogaine, focusing on the design of a safe, supportive, and clinically rigorous environment that optimizes patient outcomes. This includes the creation of structured psychological support systems, detailed patient preparation procedures, and integrated post-treatment protocols to ensure continuity of care and long-term therapeutic benefit. The protocol must be grounded in evidence-based practices and tailored to address the unique physiological and psychological demands of ibogaine therapy, with an emphasis on harm reduction, informed consent, and ethical standards. The work is being procured as a subcontract under the Advanced Research Projects Agency for Health, part of the Department of Health and Human Services, with a submission deadline of October 15, 2026. The project falls under NAICS code 621399, reflecting its focus on specialized medical services involving non-traditional therapeutic modalities. While the place of performance and point of contact details are not specified, the initiative aims to advance clinical frameworks for psychedelic-assisted therapies and requires a multidisciplinary approach integrating medical, psychological, and environmental design elements. Success will depend on delivering a replicable, scalable model that meets federal standards for safety, efficacy, and patient-centered care.