Ultrafast Microscope Camera

The National Institute of Standards and Technology, within the Department of Commerce, is seeking innovative solutions to advance the characterization of gene delivery nanoparticles through the development of ultrafast microscope camera technology. This effort supports the gene therapy manufacturing innovations in measurement sciences project under the Biosystems and Biomaterials Division, aimed at addressing critical heterogeneity challenges in viral and non-viral gene therapy vectors. The goal is to enable rapid, high-precision, multi-attribute measurements of individual nanoparticle physical properties using light-scattering microscopy, thereby accelerating the development and ensuring the safety and efficacy of next-generation gene therapies. The project will focus on enhancing measurement science tools to provide detailed, single-particle analysis that current methods cannot achieve reliably or quickly. The contract, identified by solicitation number 1333ND26QNB640413, is open for responses until August 14, 2026, with a posted date of August 4, 2026. It falls under NAICS code 334516 and is categorized as a combined opportunity with no set-aside designation. All performance will occur in Gaithersburg, Maryland, where the Material Measurement Laboratory is located. Primary point of contact is Rene D. Edwards, reachable at rene.edwards@nist.gov or 301-975-6107, with Robert Singman as the secondary contact at robert.singman@nist.gov or 301-975-6388. Interested parties must submit proposals through the SAM.gov portal linked in the contract details.