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Universal Platform for Living Adaptive Toxin-removal (UNI-PLAT)

Active
ARPA-H 03SBIR / STTR

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

AI Contract Overview

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The contract seeks to develop a universal, modular synthetic biology platform designed to create advanced microbial chassis with customizable, programmable functions. Initially focusing on toxin removal as a proof-of-concept for managing chronic diseases, this platform is intended to be versatile and scalable, applicable across various fields including environmental cleanup, biomanufacturing, agriculture, comprehensive medical applications, and therapeutic research. The aim is to produce a stable, reliable microbial system that can be easily reprogrammed to tackle a wide range of challenges beyond the initial health-related use case. This solicitation is issued by the Advanced Research Projects Agency for Health (ARPA-H) under the Department of Health and Human Services, with a total small business set-aside status encouraging participation from companies with fewer than 500 employees. The opportunity was posted in June 2026, with responses due within a month, targeting innovation under the Universal Platform for Living Adaptive Toxin-removal (UNI-PLAT) initiative. The effort embodies a cross-sector approach to synthetic biology, seeking transformative impacts across health and industry by enabling next-generation living systems capable of adaptive and programmable biological functions.

General Info

Develop universal synthetic biology platform for programmable microbial toxin removal, targeting health and industry.

Agency

Department of Health and Human Services → Arpa-HView Agency

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)View NAICS

Place of Performance

Not specified

Set-Aside

SBA

Documents

(0)

No documents available

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Timeline

1 update
PhaseSolicitation
Posted

Solicitation

Amendment 0

Contract was updated

Response Deadline

Submission deadline

Response Deadline

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Organization & Contact Information

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AgencyDepartment of Health and Human Services → Arpa-H
ContactsNo contacts available
OfficeUS
Organization / Agency
Department of Health and Human Services → Arpa-H
View Agency Profile
Office AddressUS
ContactsNo contact information available

Full Description

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The purpose of this topic area is to catalyze the development of a universal, “plug-and-play” synthetic biology platform that enables next-generation microbial chassis capable of performing a broad array of programmable functions. While this solicitation primarily uses toxin removal as a proof-of-concept in relation to chronic disease management, the platform is intended to be adaptable to a range of challenges across industries such as environmental remediation, biomanufacturing, agriculture, holistic medicine, and therapeutic discovery. The broader goal is to create a stable, reliable, and easily reprogrammable microbial platform that demonstrates potential for cross-sector impact beyond the initial use case.

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