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Upgrade to the Zeiss Serial Block Face Scanning Electron Microscope

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75N98026Q00902Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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The National Institute of Biomedical Imaging and Bioengineering (NIBIB) intends to award a sole source contract to Carl Zeiss for an upgrade to an existing Zeiss Serial Block Face Scanning Electron Microscope used for three-dimensional imaging of cells and tissues. The upgrade is restricted to the original equipment manufacturer due to the proprietary nature of the instrument’s hardware, software, firmware, and system integration, all of which are exclusively developed and controlled by Carl Zeiss. Third-party vendors lack access to the necessary technical specifications, source code, calibration procedures, and engineering documentation required to perform the upgrade, making it impossible for any other provider to meet the agency’s performance requirements. The system’s functionality depends on precise compatibility between its integrated components, and only Carl Zeiss can guarantee proper alignment, calibration, and validation using proprietary tools and factory-certified engineers. Any non-authorized modification would void warranties, invalidate service agreements, and jeopardize future software updates and technical support. No competitive alternative exists that can deliver an equivalent upgrade while preserving the instrument’s performance, research continuity, or compatibility with existing datasets and workflows. The government has determined that no other responsible source can satisfy the requirement under FAR 6.302-1. A capability statement from any interested party may be submitted by August 7, 2026, to assess potential competition, but the award is expected within five days of that date unless a viable competitor is identified. The contract will be administered by NIBIB in Bethesda, Maryland, with primary contact through Trish Haun at haunp@mail.nih.gov.

General Info

NIBIB to award sole source upgrade to Carl Zeiss for proprietary electron microscope, no viable alternatives exist.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

334516 - Analytical Laboratory Instrument ManufacturingView NAICS

Place of Performance

Bethesda, MD, 20892, USA

Set-Aside

NONE

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No documents available

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao
Contacts1 person available
OfficeBETHESDA, MD, 20892, USA
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health Olao
View Agency Profile
Office AddressBETHESDA, MD, 20892, USA
Contacts
Trish Haun
contact@example.gov

Full Description

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Authority: FAR 6.302-1 – Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements


Contracting Activity:
National Institute of Biomedical Imaging and Bioengineering (NIBIB)


Proposed Contractor:
Carl Zeiss


Description of Requirement
This is an upgrade to the Zeiss Serial Block Face Scanning Electron Microscope.  This instrument is used to study the three-dimensional structure of cells and tissues using the serial block face (SBF) imaging technique using an ultramicrotome built into the specimen chamber of the SEM.


Justification for Sole Source
NIBIB intends to negotiate and award a sole source contract to Carl Zeiss pursuant to FAR 6.302-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements. The proposed upgrade is for an existing Zeiss Serial Block Face Scanning Electron Microscope (SBF-SEM) manufactured by Carl Zeiss AG. This upgrade must be carried out by the original equipment manufacturer because:
1.    Proprietary Technology 
o    The upgrade involves proprietary hardware, software, firmware, and system integration developed exclusively by Carl Zeiss. 
o    The technical specifications, source code, calibration procedures, and engineering documentation necessary to perform the upgrade are not available to third-party vendors. 
2.    System Compatibility 
o    The microscope is an integrated instrument whose imaging performance depends on precise compatibility between the microscope hardware, detectors, stage controls, software, and Serial Block Face system. 
o    Only Carl Zeiss can ensure that the upgraded components are fully compatible with the existing instrument configuration. 
3.    Factory Calibration and Validation 
o    Following installation, the upgraded system requires factory-approved calibration, alignment, and performance verification to meet manufacturer specifications. 
o    These procedures require proprietary service tools, software, and trained factory-certified engineers. 
4.    Preservation of Warranty and Service Support 
o    Installation by any non-authorized organization could invalidate manufacturer warranties, future service agreements, software support, or eligibility for future upgrades. 
o    Carl Zeiss maintains responsibility for continued maintenance, software updates, and technical support of the upgraded system. 
5.    No Equivalent Alternative 
o    No other vendor has the legal authority, proprietary knowledge, or access to OEM components necessary to provide an equivalent upgrade while maintaining the instrument's specified performance. 
o    Third-party service providers cannot supply genuine Zeiss upgrade kits or certify the system to manufacturer performance specifications. 
6.    Research Continuity 
o    The upgraded system must maintain continuity with existing research protocols, imaging workflows, and previously acquired datasets. 
o    Using the OEM upgrade minimizes downtime and reduces technical risks that could negatively affect ongoing research. 


Notice to Interested Parties
This notice is not a request for competitive quotations or proposals. However, any responsible source, including small businesses, 8(a) firms, HUBZone small businesses, service-disabled veteran-owned small businesses (SDVOSBs), women-owned small businesses (WOSBs), veteran-owned small businesses (VOSBs), and small disadvantaged businesses (SDBs), may submit a capability statement demonstrating its ability to satisfy the Government's requirement.


Capability statements will be evaluated solely to determine whether a competitive procurement should be conducted. A determination by the Government not to compete the proposed requirement based upon responses to this notice is solely within the Government's discretion.


Anticipated Award
The Government anticipates making an award approximately five (5) calendar days after the closing date of this notice unless the Government determines that another responsible source is capable of satisfying the Government's requirements.


Capability statements must be submitted via email to haunp@mail.nih.gov no later than 9:00 a.m. EDT on August 7, 2026.
 

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UV TRANSILLUMINATOR AND CHEMILUMINESCENE INAGING SYSTEM TRAThe National Institutes of Health, through the National Institute of Diabetes and Digestive and Kidney Diseases, is seeking a replacement ultraviolet transilluminator and chemiluminescence imaging system to restore critical laboratory functionality for the Liver Diseases Branch. The current system has failed and cannot be repaired, and its absence is impeding ongoing research into liver diseases and viral infections by preventing the visualization and documentation of biological samples essential for analyzing experimental outcomes. This equipment is vital to federally funded studies aimed at understanding viral mechanisms and identifying potential therapeutic interventions, and without it, research progress will be significantly delayed. The requirement is tied directly to the branch’s mission to advance biomedical knowledge in liver health. The solicitation, identified as 75N98026Q00891AZUREBIOSYSTEMS, was posted on July 28, 2026, with a response deadline of August 6, 2026, and is categorized as a presolicitation with no set-aside designation. The NAICS code 339999 identifies it under miscellaneous manufacturing, and the contract will be awarded to support work performed at the NIH campus in Bethesda, Maryland. The primary point of contact for inquiries is Vishnuvajjala Hanumanth Rao, reachable via email at vishnuh@mail.nih.gov, and the procurement falls under the Department of Health and Human Services. The acquisition aims to procure a single integrated system capable of meeting the specific imaging needs of the laboratory, ensuring continuity in high-priority scientific investigations.
All Other Miscellaneous Manufacturing

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NAICS: 423450
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Federal
Replacement of Existing Steris AutoclaveThe National Institutes of Health Office of Laboratory Animal Welfare is seeking to replace an existing Steris autoclave under solicitation number 75N98026Q00890, with responses due by August 12, 2026. This combined solicitation, posted on July 28, 2026, is not set aside for specific business categories and falls under NAICS code 423450 for medical and dental equipment and supplies merchant wholesalers. The contract will be awarded by the Department of Health and Human Services, with the office located in Bethesda, Maryland, and performance required at a location in Durham, North Carolina, zip code 27709. Francisca K. Wagstaff serves as the primary point of contact, reachable via email at wagstaff@nih.gov. Interested parties must submit proposals through the SAM.gov platform using the provided UI link before the deadline.
Medical, Dental, and Hospital Equipment and Supplies Merchant Wholesalers

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in 15 days
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NAICS: 334516
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Automation of NGS library preps using an Agilent Magnis NGS prep system.The National Institutes of Health, through its Office of Logistics and Operations and the Surgery Branch under Dr. Steven A. Rosenberg, intends to award a non-competitive contract to Agilent Technologies, Inc. for the automation of next-generation sequencing (NGS) library preparations using the Agilent Magnis NGS prep system. This action is based on the established use of Agilent’s SureSelect WES XT-HS/Low Input kits over the past four to five years for generating sequencing libraries from immunotherapy cancer patient tumor samples, with continuity and reproducibility being critical to ongoing clinical trials at the NIH/NCI. The acquisition is being conducted under the Federal Acquisition Regulation Part 13 Simplified Acquisition Procedures, not to exceed $350,000, and is classified under NAICS code 334516 with a $1 million size standard. The contract will follow all applicable provisions of the Federal Acquisition Circular 2026-01. This presolicitation notice is not a request for competitive bids but serves as a formal announcement of the government's intent to award a sole-source contract. Interested parties may still submit capability statements, technical and cost proposals, period of performance details, Unique Entity ID, Taxpayer Identification Number, and business size certification, all of which must be received by August 7, 2026, at 9:00 AM Eastern Time. All submissions must reference solicitation number 75N98026Q00893 and be sent electronically to James Law, the contracting officer at James.Law@nih.gov. Respondents must maintain an active registration in the System for Award Management. The government retains full discretion to proceed with a non-competitive award based on responses received or to initiate a competitive procurement if deemed appropriate. The place of performance is Bethesda, Maryland, and the contracting office is located at 6701 Rockledge Drive.
Analytical Laboratory Instrument Manufacturing

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in 9 days
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