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WGS Bioinformatics and Variant Calling Services

Active
Federal

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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This subcontract for WGS Bioinformatics and Variant Calling Services supports the NIH HANDLS study projects by providing primary and secondary analysis of raw sequencing data. The scope of work involves executing read alignment and variant calling via the DRAGEN Germline pipeline, performing joint variant calling for multi-sample VCF files, and conducting essential quality control checks for contamination, duplicates, and sex. These operations are carried out using high-performance computing systems to deliver final CRAMs, gVCFs, VCFs, and structural variant or CNV calls. Managed under NAICS code 541715 for the National Institutes of Health within the Department of Health and Human Services, the project is based in Brooklyn. The solicitation was posted on September 14, 2026, with a response deadline of September 24, 2026.

General Info

Subcontract for NIH HANDLS study providing WGS bioinformatics and variant calling services.

Agency

Department Of Health And Human Services → National Institutes Of Health OlaoView Agency

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)View NAICS

Place of Performance

Brooklyn, MD, 21225, USA

Set-Aside

NONE

Documents

This scope was carved out of 75N98026R00166.

The full solicitation package (3 documents), including the RFP, is on the prime solicitation, not on this scope.

View the prime solicitation

Whole genome sequencing for investigation of age-related chronic disease in HANDLS participants

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Organization & Contact Information

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AgencyDepartment Of Health And Human Services → National Institutes Of Health Olao
ContactsNo contacts available
OfficeN/A
Organization / Agency
Department Of Health And Human Services → National Institutes Of Health Olao
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ContactsNo contact information available

Full Description

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Performs primary and secondary analysis of raw sequencing data for prime contractors on NIH HANDLS study projects. Executes read alignment and variant calling using the DRAGEN Germline pipeline and performs joint variant calling for multi-sample VCF files. Conducts QC checks for sex, duplicates, and contamination. Uses high-performance computing (HPC) systems. Delivers CRAMs, gVCFs, VCFs, and structural variant/CNV calls.

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