CYAGEN BIOMODELS LLC

CYAGEN BIOMODELS LLC specializes in the design, generation, and production of genetically engineered mouse models for biomedical research, with deep expertise in conditional knockout and knockin technologies using CRISPR/Cas9 and embryonic stem cell methods. The company delivers end-to-end solutions for life science research, including targeted gene modification, transgenic strain development, and phenotypic characterization of complex disease models. Their technical capabilities span mammalian reproductive biology, germline transmission validation, and the production of immunocompetent, strain-specific murine models for studying inflammation, neurodegeneration, prion diseases, and hematopoietic system function. CYAGEN’s key differentiator lies in its precision engineering of conditional alleles, particularly in C57BL/6N backgrounds, and its ability to deliver viable, phenotypically validated models for in vivo studies under strict biospecimen and animal welfare protocols. The contractor maintains a strong relationship with the Department of Health and Human Services, delivering critical mouse model development and testing services to NIH institutes such as NICHD. They also support the Department of Veterans Affairs with genetically modified models for musculoskeletal and neurological research, and the Department of Agriculture with transgenic models for livestock prion disease studies. These engagements reflect a consistent focus on federally funded life sciences initiatives requiring high-fidelity, reproducible animal models. Their primary industry focus is biological product manufacturing (NAICS 325414), where they produce live genetically modified organisms as research tools, complemented by specialized research and development services in biotechnology and life sciences (NAICS 541714/541715). They also provide animal production (NAICS 112990) and laboratory testing (NAICS 541380) services, positioning them as a vertically integrated provider for preclinical research infrastructure. CYAGEN BIOMODELS LLC is a small business structured as a 2L entity based in Santa Clara, California. While currently holding no federal certifications, its technical rigor, domain-specific expertise in murine genetic engineering, and consistent delivery to major federal research agencies establish a strong reputation in the preclinical model development market.