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ISOLA THERAPEUTICS INC

UEI: M3QDM72NME75CAGE: 890E6

ISOLA THERAPEUTICS INC is a federal contractor, registered under UEI M3QDM72NME75 and CAGE code 890E6. It has been awarded $16,175,833 across 4 federal contracts. Primary work spans Research and Development in Biotechnology (except Nanobiotechnology) and Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology). Top awarding agencies include Department Of Health And Human Services and Barda - Aspr / Daappo / Barda Dcma.

Contact Information

Registration and classification details

Registration

UEI Code

M3QDM72NME75

CAGE Code

890E6

Entity Structure

Corporate Entity (Not Tax Exempt)

Established

N/A

Business Classifications

2X

NAICS Codes

334510Electromedical and Electrotherapeutic Apparatus Manufacturing
339112Surgical and Medical Instrument Manufacturing(Primary)

Federal Contracting Overview

Award totals, agency breakdown, NAICS distribution, and geographic footprint.

AI Capability Profile

Isola Therapeutics Inc. specializes in translational research and development of novel drug delivery systems for targeted therapeutic interventions in pulmonary and esophageal pathologies. The company leverages endobronchial and endoesophageal lavage technologies to repurpose existing pharmaceutical...

Isola Therapeutics Inc. specializes in translational research and development of novel drug delivery systems for targeted therapeutic interventions in pulmonary and esophageal pathologies. The company leverages endobronchial and endoesophageal lavage technologies to repurpose existing pharmaceutical agents for acute chemical threat mitigation and cancer treatment, demonstrating deep expertise in localized drug administration, aerosol pharmacokinetics, and preclinical model validation. Their work bridges life sciences innovation with defense and public health preparedness, focusing on non-invasive, high-precision delivery platforms that enhance bioavailability while minimizing systemic toxicity. Key differentiators include proprietary lavage-based delivery methodologies, adaptive formulation science, and a strong focus on repurposing therapeutics under urgent biomedical threat scenarios. The contractor maintains a focused relationship with the Department of Health and Human Services, delivering R&D solutions aligned with biomedical preparedness and oncology innovation. Their engagements center on advancing medical countermeasures against chemical agents and developing novel treatment paradigms for gastrointestinal and respiratory cancers, reflecting a strategic alignment with HHS priorities in public health resilience and precision medicine. Isola Therapeutics operates primarily within the biotechnology and life sciences R&D sectors, with NAICS 541714 and 541715 defining their core market space. They position themselves as a niche innovator in non-systemic drug delivery, serving government-funded programs focused on emergency response, oncology therapeutics, and targeted pharmacology. Their work sits at the intersection of biomedical engineering, pharmacology, and clinical translation, with minimal overlap into broader biotech domains like genomics or nanotechnology. As a small business structured as a 2L entity based in Minneapolis, Minnesota, Isola Therapeutics operates without federal certifications but maintains a focused government market presence through specialized R&D contracts. Their geographic footprint supports collaboration with regional academic and medical research institutions, reinforcing their role as a nimble, science-driven contractor in the federal biomedical innovation ecosystem.

Key Performance Metrics

Awards Count

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Total Awards

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Contracts

Prime · all time

Subcontracts

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Grants

Prime · all time

Subgrants

Sub · all time

Award Analytics & Distribution

Awards by Agency
Department Of Health And Human Services$8.7M53.7%
Barda - Aspr / Daappo / Barda Dcma$7.5M46.3%
Awards by NAICS
541714 - Research and Development in Biotechnology (except Nanobiotechnology)$8.2M50.9%
541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)$7.9M49.1%
Awards by Agency Over Time
Export
Awards by Place of Performance

Open opportunities in ISOLA THERAPEUTICS INC's top NAICS codes and agencies

NAICS: 541714
New
Federal
Humanized Antibody Library Screening and Transferrin Receptor DevelopmentThe contract involves the customized screening of a humanized antibody library to develop a functional transferrin receptor, encompassing molecular design, in vitro selection, and optimization of binding affinity and specificity. The work requires advanced techniques in antibody engineering to identify and refine candidates capable of high-affinity, selective interaction with the transferrin receptor, with the goal of producing a therapeutically viable candidate. The scope includes iterative cycles of library screening, functional characterization, and structural optimization to enhance target binding while minimizing off-target interactions, ensuring the final product meets stringent performance benchmarks. This subcontract is issued under the NAICS code 541714 for research and development in the biological sciences and is associated with the National Institutes of Health through the Department of Health and Human Services. The place of performance is in Bethesda, Maryland, with a deadline for proposals set for July 31, 2026. The contract is expected to support biomedical innovation targeting receptor-mediated delivery systems and requires expertise in molecular biology, high-throughput screening, and protein engineering. No specific set-aside provisions are indicated, and the work is open to qualified subcontractors capable of delivering scalable, data-driven antibody development solutions within the defined timeline.
National Institutes Of Health Olao

POSTED

2 days ago

DEADLINE

in 5 days
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NAICS: 541715
New
Federal
Onsite Technical Installation and Integration SupportThe contract requires the onsite technical installation, configuration, and integration of an optical processor at the Oak Ridge National Laboratory, with a strict emphasis on compliance with safety regulations and the implementation of comprehensive hazard controls. All work must be performed at the designated facility in Oak Ridge, Tennessee, 37830, and must align with the Department of Energy’s standards for operational safety, engineering integrity, and environmental protection. The subcontractor is responsible for ensuring that every phase of the project, from initial setup to final system integration, adheres to applicable federal and lab-specific safety protocols, including the identification and mitigation of potential hazards associated with the optical processor’s deployment. This is a subcontract solicited under NAICS code 541715 for research and development in physical, engineering, and life sciences, with a response deadline of July 31, 2026. The contract is managed by UT-Battelle LLC, the Department of Energy’s contractor at ORNL, and no set-aside provisions apply. The work demands specialized technical expertise in optical systems, precise integration capabilities, and a documented history of handling sensitive or high-risk equipment within a federally funded research environment. Contractors must be prepared to operate under DOE oversight, coordinate with lab personnel, and deliver all deliverables within the specified timeframe without disruptions to ongoing laboratory operations.
Ornl Ut-Battelle Llc-Doe Contractor

POSTED

2 days ago

DEADLINE

in 5 days
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NAICS: 541715
New
Federal
Capstone Project Alignment with Defense MissionsThe contract seeks to engage providers who can guide U.S. Naval Academy midshipmen in developing technical capstone projects that directly align with real-world defense missions in artificial intelligence, cybersecurity, autonomy, or logistics. These projects are intended to bridge academic learning with operational needs, ensuring future naval officers are equipped with practical, mission-relevant technical expertise. Work will be performed primarily in Annapolis, Maryland, with the focus on mentoring and supporting student teams through the full lifecycle of their project development, from concept to demonstration. This is a subcontract under NAICS code 541715, which categorizes it under research and development in the physical, engineering, and life sciences. The opportunity was posted on July 24, 2026, with a response deadline of July 29, 2026, and is administered by the Naval Supply Systems Command Fleet Logistics Center Norfolk under the Department of Defense. While specific performance metrics or funding details are not indicated, the emphasis is squarely on delivering high-impact, defense-oriented technical outcomes that enhance the readiness and innovation capacity of the next generation of naval leaders. Participation is open to entities capable of providing expert mentorship and technical oversight in the specified domains.
Navsup Flt Logistics Ctr Norfolk

POSTED

2 days ago

DEADLINE

in 3 days
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NAICS: 541715
New
Federal
Eye-Tracking and Vehicle Kinematics Data CollectionThe contract involves the collection of field data from drivers at Alternative Intersection and Interchange sites using eye-tracking devices and vehicle kinematics sensors. Responsibilities include recruiting qualified drivers, deploying and Calibrating sensory equipment in real-world traffic environments, and ensuring all collected data is properly anonymized to protect participant privacy. The work requires technical expertise in sensor deployment, data acquisition protocols, and strict adherence to data privacy standards to maintain the integrity and confidentiality of the information gathered. This effort supports research into driver behavior and traffic safety at unconventional intersection designs. The solicitation is classified as a subcontract under NAICS code 541715, indicating it falls within the category of research and development in the physical, engineering, and life sciences. It was posted on July 24, 2026, with a firm response deadline of August 11, 2026, at 3:00 PM. The contracting agency is the Department of Transportation under the 693JJ3 Acquisition and Grants Management office. While specific location details for performance or contact information are not provided, the work is expected to take place across multiple Alternative Intersection and Interchange sites. Participation requires strict compliance with data handling procedures and operational logistics for field research under real traffic conditions.
693JJ3 Acquisition And Grants Mgt

POSTED

2 days ago

DEADLINE

in 16 days
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NAICS: 541715
New
Federal
Mobile Integrated Launch CapabilityThe Missile Defense Agency is seeking innovative solutions through a continuous solicitation for the Mobile Integrated Launch Capability to enhance the efficiency and global responsiveness of target missile system launches, replacing current C-17 air drop methods. This two-phase effort requires contractors to first provide detailed design, engagement analysis, and cost estimates for novel mobile launch concepts in Phase I, followed by prototyping, ground testing, and a live launch demonstration of a selected system in Phase II. The work must adhere to open system architecture principles, prioritize commercial-off-the-shelf and government-off-the-shelf technologies, and achieve defined development milestones to support future acquisition decisions. The primary place of performance is Redstone Arsenal, Alabama, though the launch capability must be deployable worldwide. Offerors must have an active Secret Facility Clearance Level verified by MDA prior to award, as the project involves handling Secret and Controlled Unclassified Information under NIST SP 800-171 and DFARS requirements, with strict compliance mandated for data safeguarding, export controls under ITAR and EAR, and organizational conflict of interest disclosures. Proposals are submitted as a single white paper with strict formatting rules—no more than 10 pages for the executive summary and program description, using 12-point font and one-inch margins—and must include a Rough Order of Magnitude cost estimate, program plan, and details of prior relevant work. There is no fixed budget or funding ceiling, and awards are made on a trade-off basis weighing technical merit, program relevance, and cost realism, with the Government retaining the right to negotiate either a FAR-based contract or an Other Transaction agreement. Contractors must be registered in SAM with a valid UEI, disclose their size status, and assume responsibility for at least half the total effort cost. Submission is ongoing through SAM.gov, with electronic delivery via email for unclassified and CUI materials and hard-copy courier for Secret submissions, and all proposals are evaluated continuously without a final closing date.
Missile Defense Agency (mda)

POSTED

2 days ago

DEADLINE

in about 2 years
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