SIMULATIONS PLUS INC

Simulations Plus Inc. specializes in the development and licensing of advanced computational pharmacology and pharmacokinetic modeling software, enabling precise simulation of drug absorption, distribution, metabolism, and excretion across multiple administration routes—including oral, intravenous, dermal, and inhalation pathways. Their core capabilities center on ADMET Predictor and GastroPlus platforms, which deliver predictive in silico modeling for pharmaceutical research, regulatory submissions, and preclinical safety assessment. The company provides integrated software solutions that support quantitative systems pharmacology, bioavailability prediction, and species scaling, serving as critical tools for drug discovery and development workflows. Their technical expertise lies in mechanistic modeling, physiologically based pharmacokinetics (PBPK), and cheminformatics, with a focus on delivering validated, FDA-recognized tools that reduce reliance on animal testing and accelerate regulatory decision-making. Simulations Plus Inc. maintains a strong presence with the Department of Health and Human Services, where they supply licensed software for drug safety and pharmacokinetic analysis, and the Department of Defense, which utilizes their platforms for military-relevant pharmacological research and medical countermeasure development. The Environmental Protection Agency also engages them for toxicokinetic modeling applications. These relationships reflect consistent, long-term procurement patterns centered on software licensing and technical support rather than custom development. The contractor operates primarily under NAICS 511210 and 513210, positioning itself as a niche software publisher in computational life sciences, distinct from general IT services. Their market focus is exclusively on pharmaceutical, biotech, and regulatory science sectors requiring high-fidelity in silico modeling. As a small business headquartered in Lancaster, California, with no federal certifications, Simulations Plus Inc. competes on technical rigor and domain-specific software validation, serving government agencies that require scientifically robust, peer-reviewed modeling tools for drug and chemical safety evaluation.