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Contract Overview

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The contract outlines research activities at the National Institute of Standards and Technology (NIST) involving the development of innovative technologies centered around temperature gradient focusing and solid-state radiance calibration sources. One key technology involves using temperature gradient focusing (TGF) to enhance analyte-ligand interactions, which can include various biochemical and chemical reactions such as nucleic acid hybridizations, enzyme-substrate reactions, protein interactions, and drug-target binding. This method allows for detailed analysis through the manipulation of the temperature gradient, providing insights into temperature-dependent reactions like nucleic acid duplex melting or polymer precipitation. Another development focuses on chiral temperature gradient focusing, a variation that incorporates chirally selective additives to separate analytes based on their chirality by altering electrophoretic mobility. Additionally, the contract describes the creation of a compact, LED-based solid-state radiance calibration source designed to provide temporally stable, spatially uniform, and radiometrically calibrated light at multiple wavelengths. This source addresses the need for portable calibration tools in radiation thermometry, enabling accurate initial characterization and ongoing verification of size-of-source effects without the bulk of traditional integrating sphere sources. Materials for optimizing spatial and angular uniformity have been evaluated to improve the performance of these radiometric instruments. The contract is managed by the Department of Commerce’s NIST office, with a designated contact for further inquiries.

General Info

NIST develops temperature gradient focusing and LED-based solid-state radiance calibration technologies.

Agency

Department Of Commerce Nist

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Set-Aside

NONE

Documents

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Timeline

PostedMar 4

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Organization & Contact Information

AgencyDepartment Of Commerce Nist

Contacts1 person available

OfficeGAITHERSBURG, MD, 20899, USA

Organization / AgencyDepartment Of Commerce Nist

Office AddressGAITHERSBURG, MD, 20899, USA

Contacts

Susan K BrinkmanContract Specialist

contact@example.gov

+1 (555) 000-0000

Full Description

Researchers at the National Institute of Standards and Technology (NIST) are working on the following technologies. For further information, contact the: National Institute of Standards and Technology, Office of Technology Partnerships, 100 Bureau Drive, Stop 2200, Gaithersburg, Maryland 20899; Fax: +1 (555) 000-0000. This is not an announcement of a contract action or a grant. **NIST DOCKET NUMBER: 01-029CIP1 Title: Mixing Reactions by Temperature Gradient Focusing Description: The new use of TGF in this invention involves analyte-ligand interactions that occur as a result of focusing one (the ligand or analyte) and allowing interactions with the second (analyte or ligand) to occur. The mixing interaction can be a hybridization event between nucleic acids such as single stranded DNA/DNA or DNA/peptide nucleic acid (PNA), a chemical reaction, an enzyme/substrate reaction, a protein/protein, or drug/target interaction. In addition, moving the focused product through the temperature gradient after mixing allows additional information to be inferred if the assay displays a temperature dependent interaction (i.e. nucleic acid duplex melting or precipitation of thermoresponsive polymers). **NIST DOCKET NUMBER: 01-029CIP2 Title: Chiral Temperature Gradient Focusing Description: The invention describes a variant of temperature gradient focusing that uses chirally selective additives to modify the electrophoretic mobility of analytes thereby providing a method for focusing and separation of analytes based on their chirality. **NIST DOCKET NUMBER: 04-018 Title: Solid State Radiance Calibration Source Description: With the development of light-emitting diodes (LED) at many different wavelengths, compact, quasi-monochromatic sources can be developed for radiometric uses. Temporally stable, spatially uniform and radiometrically calibrated sources are needed in many different applications. Instead of using large integrating sphere sources, such radiance sources can also be used to measure the size-of-source effect (SSE) in radiation thermometers. These compact sources can be used for both initial characterizations and for periodic measurements to determine that the SSE has not changed. This invention describes the design, construction, and characterization of a unique LED-based radiance source (LRS). Different diffuser materials are assessed for spatial and angular uniformity.