A -- FOLIC ACID METHYLATION PROJECT

The Centers for Disease Control and Prevention intends to award firm fixed price purchase order to University of Florida Food Science and Human Nutrition Department, Gainesville, FL to provide research data and services for (0001) Global DNA methylation changes accompany folic acid supplementation; (0002) DNA methylation changes; genotype specific; (0003) DNA methylation response on the folic acid dose; (0004) DNA methylation changes significantly within 3 months of stopping folic acid supplementation; (0005) The interactive effect of multiple folate-related polymorphisms on DNA methylation response to folic acid supplementation. The purpose of this study is to determine if there are global DNA methylation changes in response to folic acid supplementation and if observed changes are genotype and dose dependent. This is an on-going study and the University of Florida is the only source to provide the specific global DNA methylation and critical timeframe for this study deeemed necessary by CDC. utilize DNA samples that were collected in from women in China, where there is no food fortification with folic acid and dietary sources of folate are limited, were given folic acid supplements in varying doses over a 6 month time period in order to determine the optimal folic acid dose. Blood samples were taken at the beginning of the study as well as at 1, 3, 6 and 9 months (3 months post-supplementation). CDC intends to negotiate this requirement with University of Florida under the authority of FAR 6.302-1, HHSAR 306.302-1, and 10 U.S.C. 2304(c)(1). The sole source procurement will be awarded as a simplified acquisition in accordance with FAR Subpart 13 procedures. This notice of intent is not a request for competitive proposals. A determination to compete this procurement based on a response to this notice is solely within the discretion of the Government. Interested parties who believe they possess the capabilities to satisfy this requirement should submit a capability statement demonstrating their abilities to meet this requirement. All responses should be received by the closing date of this synopsis to be considered by CDC. All responses must be in writing and can be sent via email to contact@example.gov or fax to +1 (555) 000-0000 Attn: Matthew Ellington. No phone calls will be accepted. Note: 22