A -- Botulinum Toxin Purification and Evaluation of Subtyping Methodologies

The Centers for Disease Control and Prevention intends to issue a sole source purchase order to Food Research Institute, University of Wisconsin, Madison, Wisconsin for a Botulinum Toxin Purification and Evaluation of Subtyping Methodologies. Responsibilities for this project include purification of unusual subtypes of botulinum neurotoxin from cultures of Clostridium botulinum as well as purification of botulinum neurotoxin from a variety of Clostridium botulinum foodborne. Specifically, the laboratory will provide botulinum toxin complexes from A1, A2, A3, and potentially A4 C. botulinum strains. Recombinantly produced light chains may be provided instead of A3 and A4 toxins if sufficient quantities cannot be isolated from C. botulinum cultures. Botulinum neurotoxin complexes will be isolated from ten type A, ten proteolytic type B and ten nonproteolytic type B C. botulinumcultures. Complexes will be purified from B1, B2, and B3 C. botulinum variants, or alternatively, recombinant light chains from B1, B2, and B3 if sufficient quantities of complex cannot be isolated from C. botulinum culture.CDC believes that this requirement is met by only one provider. This procurement will be processed under the authority of FAR 6.302-1 and 6.302-2. Only one responsible source and no other sources will satisfy agency requirements. No solicitation is being issued. However, information received will be considered solely for information purposes only. This procurement is not set-aside for small business. For contractual questions contact Beth West at contact@example.gov