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A -- Tissue-Based Small Animal Model for HIV Drug Discovery

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Reference-Number-SN-NIH-NIAID-DAIDS-07-21Federal

Contract Overview

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AI Contract Overview

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), plans to negotiate a multi-year contract with the University of California, San Francisco (UCSF) to leverage a specialized small-animal model for testing potential HIV-1 therapies. This model utilizes immunodeficient mice engrafted with human fetal thymus and liver tissue (SCID-hu Thy/Liv) and infected with well-characterized HIV-1 isolates. UCSF is uniquely qualified to perform in vivo evaluations of HIV-1 therapeutics, assessing both efficacy and toxicity using this validated animal system with a diverse panel of HIV-1 strains. The contract negotiation is justified under statutory provisions allowing other than full and open competition, specifically 41 U.S.C. 253(c)(1) and FAR 6.302-1, given UCSF’s exclusive capabilities and specialized resources. The contract is identified with solicitation number SN-NIH-NIAID-DAIDS-07-21 and was initially posted in June 2006. The point of contact for this opportunity is Nancy Hershey, Contract Specialist at NIAID, available via phone or email for further inquiries.

General Info

NIAID to contract UCSF for specialized HIV-1 therapy testing using SCID-hu Thy/Liv mice.

Agency

N/A

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

Not specified

Set-Aside

NONE

Documents

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Timeline

PhaseSources Sought

PostedJun 20

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Organization & Contact Information

AgencyN/A

Contacts1 person available

OfficeN/A

Organization / Agency

N/A

Office AddressN/A

Contacts

Nancy M HersheyContract Specialist

contact@example.gov

+1 (555) 000-0000

Full Description

The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) intends to negotiate with the University of California, San Francisco (UCSF) for a multiple-year contract to utilize a small-animal model to evaluate potential therapies for HIV-1 infection. The animal model being used is an immunodeficient mouse engrafted with human fetal thymus and liver (SCID-hu Thy/Liv) and infected with well-characterized isolates of HIV-1. UCSF possesses a unique capability to evaluate potential HIV-1 therapeutics, alone and in combination, for efficacy and toxicity in vivo, in a validated animal model consisting of SCID mice engrafted with human fetal thymus and liver (SCID-hu Thy/Liv) tissue and infected with a diverse panel of well characterized primary isolates and molecular clones of HIV-1. The statute justifying this other than full and open competition is 41 U.S.C. 253(c)1) and FAR 6.302-1. See Numbered Note 22. Point of Contact Nancy Hershey, Contract Specialist, Phone 301-496-0193, Fax (301) 402-0972. Email: nhershey@niaid.nih.gov.