This Government Contract opportunity from Department Of Health And Human Services was posted on December 2, 2024. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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ADVANCING CLINICAL TRIALS READINESS (ACTR)

Closed

ARPA-H-SN-25-121Federal

Submission Closed01/30/2025, 06:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541715

New

Federal

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AI Research & PrototypingThe AI Research and Prototyping subcontract supports Department of the Air Force CDAO projects by developing research products, functional prototypes, and test results for new AI environment capabilities. The scope of work includes conducting research on AI environment architectures and executing tests for new AI tools to create operational capabilities for prime contractors. Due to the sensitive nature of the work, a TS/SCI clearance is required for personnel. The project is managed under the Department of Defense via the FA7014 Afdw Pk agency, with a response deadline of November 2, 2026. Final deliverables consist of comprehensive research reports, functional prototypes, and validated test results.

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AI/ML Model Development & Algorithmic DesignThis subcontract focuses on the design, development, fine-tuning, and testing of advanced AI/ML models to support prime contractors on Department of the Air Force CDAO projects. The scope of work involves applying supervised, unsupervised, and reinforcement learning, deep neural networks, and probabilistic modeling. Technical execution requires the use of accelerated computing resources, such as GPUs and TPUs, alongside industry-standard frameworks including PyTorch and TensorFlow to deliver validated algorithmic capabilities. Due to the sensitive nature of the Department of Defense projects, all personnel must possess a TS/SCI security clearance. The contract is categorized under NAICS code 541715 and is associated with the agency FA7014 Afdw Pk. Interested parties should note the response deadline of November 2, 2026.

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Historical Research & Archival ServicesThis subcontract for Historical Research and Archival Services supports prime contractors on DPAA projects under the Department of Defense, specifically through Washington Headquarters Services. The selected provider will utilize professional historical expertise and government record access to perform complex research aimed at contextualizing loss incidents. Key responsibilities include conducting archival research, developing detailed case narratives of individuals or conflicts, and generating targeted lists of potential recovery locations based on historical evidence. The work is designated under NAICS code 541715 and will be performed in Alexandria, Virginia. Interested parties must submit their responses by November 9, 2026, at 3:00 PM. The primary deliverables for this engagement are the completed case narratives and the identified lists of potential recovery sites.

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DEADLINE

Common Autonomous Multi-Domain Launcher (CAML)-Lite Prototype Effort

Solicitation # W50RAJ27CAML_LITE

The Common Autonomous Multi-Domain Launcher (CAML)-Lite Prototype Effort is a competitive procurement conducted under 10 U.S.C. section 4022 Other Transaction Authority to develop a mobile, optionally manned, autonomous launcher for cross-domain offensive and defensive fires. The program is structured in two phases, beginning with Phase 1, which requires a prototype demonstration at Talisman Sabre 2027 in August 2027. This initial phase includes a priced option for the acquisition of additional prototype units, New Equipment Training, and Contractor Logistics Support. Phase 2 focuses on prototype maturation and integration into a common CAML architecture. The government seeks solutions that utilize a Modular Open Systems Approach to ensure interchangeable modules and autonomous munition resupply with minimal human intervention. The procurement process begins with the submission of a Solutions Brief, with a deadline of October 26, 2026. The government will evaluate these briefs based on technical soundness, credibility in addressing objectives, and the feasibility of the maturation path to select the most meritorious respondents for a subsequent Request for Prototype Proposal. Award for Phase 1 is expected by December 18, 2026. Selected performers must assume full responsibility for international logistics and compliance for transporting systems to Australia. Funding for the demonstration will be provided at initial award, though performer investment is required and may positively influence selection. Final acceptance of the effort is contingent upon successful performance verification, cybersecurity Authority to Operate, and government approval of the Technical Data Package.

W6DV Peo M & S Redstone

POSTED

DEADLINE

Protein Palace Proposers Day

Solicitation # DARPA-SN-27-01

The Defense Advanced Research Projects Agency (DARPA) is initiating the Protein Palace program to develop a universal, tunable protein purification platform. This initiative aims to replace the traditional lock-and-key paradigm with a system capable of purifying multiple proteins from a single system by leveraging unique physicochemical characteristics to improve specificity, generalizability, and scalability in biomanufacturing. The program is structured into two distinct phases: a 24-month Phase 1 focused on proving feasibility and specificity by separating eight different proteins, followed by an 18-month Phase 2 focused on increasing throughput and volume, demonstrated on two additional proteins that are difficult to purify using current state-of-the-art methods. To support this effort, DARPA is hosting an in-person Proposers Day on November 17, 2026, from 9:00 a.m. to 4:00 p.m. ET at the Executive Conference Center in Arlington, Virginia. Interested parties must register by November 9, 2026, and provide government-issued photo identification for entry. While the current Special Notice DARPA-SN-27-01 is for information and planning purposes and does not constitute a formal solicitation, DARPA anticipates releasing the full solicitation on sam.gov prior to the event. The Proposers Day will be held at the unclassified level, and any presented materials must be suitable for unlimited public release.

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POSTED

DEADLINE

Federal Aviation Administration (FAA) Research And Commercial Solutions Opening (RCSO) Area Of Interest (AOI) - Complexity Of Systems And Operations

Solicitation # 693KA8-27-T-00003

Solicitation 693KA8-27-T-00003 is a request from the Federal Aviation Administration for innovative research and solutions regarding the Complexity of Systems and Operations. This effort falls under the broader Research and Commercial Solutions Opening BAA-693KA8-26-RCSO and focuses on aviation safety research to advance the understanding of human factors and performance. Specifically, the agency is seeking solutions that address complexity from the perspectives of pilots and aircraft maintenance personnel, covering areas such as pilot-machine interfaces, the explainability of complex automation and artificial intelligence, and the mental models used for monitoring and troubleshooting complex systems. The goal is to produce high-quality human factors data, rigorously documented analyses, and actionable tools or criteria to enhance the National Airspace System. The procurement process is phased, beginning with the submission of Research/Solution Briefs, followed by Pitch Sessions, and concluding with a Request for Proposal for selected entities. Submissions are evaluated based on technical merit, innovation, relevance to the problem statement, and feasibility. Successful candidates will be awarded Other Transaction Agreements (OTAs), with terms and conditions negotiated directly between the Agreements Officer and the selected entity. All submissions must be unclassified, and the agency encourages participation from nontraditional government contractors, including small businesses. The response deadline for this specific Area of Interest is November 2, 2026.

693KA8 System Operations Contracts

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Technology Validation & Safety TestingThis subcontract for Technology Validation and Safety Testing supports prime contractors on National Institutes of Health translational development projects. The primary objective is to perform experiments that validate the safety and effectiveness of developed technologies for specific populations. This work involves executing validation experiments and effectiveness benchmarking through the use of specialized sensors and laboratory testing equipment. The selected provider must hold GLP or GCP certifications to ensure compliance with regulatory standards. Key deliverables for this engagement include comprehensive validation reports and detailed safety and effectiveness data sets. The contract falls under NAICS code 541715 and is associated with the Department of Health and Human Services.

National Institutes Of Health

POSTED

DEADLINE

Medical Device Prototype Development & OptimizationThis subcontract focuses on the technology development and optimization of next-generation diagnostic and therapeutic devices for prime contractors working on National Institutes of Health translational development projects. The scope of work involves refining device prototypes and optimizing hardware and software for clinical application through the use of biocompatible materials, medical-grade electronics, and rapid prototyping tools. The project requires strict adherence to ISO 13485 quality management standards to ensure the final output is a functional, optimized device prototype ready for validation. This effort falls under NAICS code 541715 and is associated with the Department of Health and Human Services.

National Institutes Of Health

POSTED

DEADLINE

First Article Test (FAT) SpecialistThis subcontract opportunity is for a First Article Test Specialist to perform prototype manufacture and validation testing for prime contractors supporting DLA Weapons Support combat vehicle projects. The selected provider will produce one initial unit and conduct rigorous testing using flow, pressure, and integrity measurement equipment to ensure strict adherence to technical drawings 19207 8338562 and 19207 12342887. The final deliverables for this project include one fully tested unit and a comprehensive test report. The contract is a total small business set-aside under NAICS code 541715, with performance taking place in Barstow, California. Compliance requirements are stringent, necessitating US/Canada Joint Certification Program approval and adherence to DFARS 252.204-7012 standards. Interested parties must respond by November 2, 2026.

DLA WEAPONS SUPPORT LSO COMBAT VEHICLES AND ARMAMENT

POSTED

1 day ago

DEADLINE

in 10 days

General Info

Agency

Department Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

NAICS

541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)

Place of Performance

DC, USA

Set-Aside

NONE

Documents

No documents available

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Timeline

PhaseClosed

PostedDec 2

special-notice

Response DeadlineJan 30

Deadline has passed

Submission Closed

01/30/2025, 06:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Contacts1 person available

OfficeWashington, DC, 20005, USA

Organization / AgencyDepartment Of Health And Human Services → Advanced Research Projects Agency For Health (arpa-H)

Office AddressWashington, DC, 20005, USA

Contacts

ACTR Box

contact@example.gov

Full Description

The Advanced Research Projects Agency for Health (ARPA-H) is hosting a hybrid Proposers Day in support of a planned solicitation for the ACTR Initiative. Registration, date, time, and additional information can be found at: https://www.customerexperiencehub.org/advancing-clinical-trial-readiness-actr/