This Government Contract opportunity from Department Of Defense was posted on April 14, 2026. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Antibacterial Nanoparticles Therapeutic (ANT) Study

Closed

PANDHA-26-P-0000_036893Federal

Submission Closed04/28/2026, 06:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

Active Opportunities Like This One

NAICS: 541713

New

SBIR / STTR

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The USDA SBIR/STTR Topic 8.1 solicitation, managed by the National Institute of Food and Agriculture, seeks innovative technologies to enhance the health, productivity, and sustainability of national forests and grasslands. The program prioritizes the development of environmentally sound approaches to increase forest productivity, improve resource sustainability, and create value-added materials from woody resources. Specific areas of interest include sustainable bioenergy, biofuels derived from woody biomass, the impact of climate change on forest health, and the application of nanotechnology in wood-based products. Over a ten-year horizon, the program aims to increase the utilization of woody resources for high-value products and foster forest ecosystems that are more resilient to wildfires, pathogens, and climate-related disturbances. Key goals include improving the economic and environmental methods of sustainable harvesting and enhancing the growth and yield of forest species for more efficient land use. This opportunity is a total small business set-aside restricted to entities with fewer than 500 employees.

National Institute of Food and Agriculture

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DEADLINE

Nanotechnology Orchestrated Viral Annihilation (NOVA) – DTRA

Solicitation # 5fc9b9c3-3c66-4cf1-bd23-c37a93301889

The Department of Defense, through the Defense Threat Reduction Agency, is seeking prototypes for nanotechnology-based medical countermeasures to protect warfighters from multiple viral threats. Moving away from the traditional one-virus, one-countermeasure model, this initiative aims to develop broad-spectrum, biocompatible, and biodegradable solutions capable of functioning in both pre- and post-exposure scenarios. The goal is to create a versatile platform that can neutralize various viruses while simultaneously mitigating inflammatory fallout from preexisting infections. The project is divided into three lines of effort focusing on prototype demonstration, ruggedization, and scalability. The first phase requires a prototype that demonstrates activity against at least five viruses in vitro and one virus in vivo, utilizing cellular decoy and immunomodulatory mechanisms. The second phase focuses on creating heat-stable, ruggedized formulations suitable for multiple administration routes in austere environments. Finally, the effort requires the development of a scalable manufacturing process and a defined regulatory pathway toward FDA licensure to ensure the technology can transition from nonclinical demonstration to clinical use.

Department Of Defense

POSTED

DEADLINE

Operando Measurements for Electrochemical Surfactant-Mediated Growth Mechanisms for Interconnect MaterialsThe Department of Commerce is seeking technical research support to conduct operando electrochemical measurements focused on surfactant-mediated metal deposition processes. This effort supports the CHIPS Act project titled Electrodeposition of Interconnect Materials and Packaging, with a primary goal of understanding the mechanisms behind the electrochemical deposition of copper and alternative interconnect metals such as rhodium and iridium. The selected contractor will utilize operando measurements and surface science techniques to investigate nucleation and growth processes. Specific research will emphasize how interfacial structures and metal deposition are influenced by the co-adsorption and competitive adsorption of cations, anions, halides, surfactants, suppressors, and other additives. The work is slated to be performed in Gaithersburg.

POSTED

DEADLINE

Theoretical/Applied Research ScientistThis subcontract for a Theoretical/Applied Research Scientist supports the Defense Advanced Research Projects Agency within the Department of Defense. The role focuses on conducting high-risk, high-reward research to secure fundamental scientific breakthroughs for prime contractors. Key responsibilities include investigating innovative approaches to drive revolutionary advances through the use of specialized simulation software and high-performance computing. The contractor is required to deliver theoretical models, validated experimental data, and scientific papers while maintaining compliance with NIST SP 800-171 standards for the protection of controlled unclassified information. This opportunity falls under NAICS code 541713 and has a response deadline of June 1, 2027.

Defense Advanced Research Projects Agcy

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Magnetic resonance spectrometerThe Department of Commerce is forecasting the acquisition of an x-band continuous wave electron spin resonance spectrometer to support the Nanoscale Device Characterization Division in PML. This equipment is intended to enhance quantum-based sensing efforts by enabling the measurement of the chemical and physical properties of atomic-scale defects in solid-state materials, which is critical for applications such as magnetometry. The procurement aims to expand existing electron spin resonance infrastructure to accommodate an increasing demand for characterization services. The work will be performed in Gaithersburg, and the project is categorized under NAICS code 541713. Interested parties may contact Hannah Lee or the DOC OSDBU for further information.

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DEADLINE

Natural Language Processing for Aviation Audio CommunicationsThe NASA SBIR/STTR Program is seeking a subcontractor to design and demonstrate the feasibility of utilizing speech-to-text and natural language processing to identify errors within controller-pilot communications. The primary objective of this effort is to implement transcription validation and error classification to improve the safety and accuracy of aviation audio communications. This project is designated as a Total Small Business Set-Aside under NAICS code 541713 and is managed by the National Aeronautics and Space Administration. Performance for this contract is centered at Moffett Field, California, with the official posting date listed as August 20, 2026.

NASA SBIR/STTR Program

POSTED

DEADLINE

Operando Measurements for Electrochemical Surfactant-Mediated Growth Mechanisms for Interconnect MaterialsThis contract seeks technical research support for the Department of Commerce to conduct operando electrochemical measurements focused on surfactant-mediated metal deposition processes. The primary objective is to support NIST research into the mechanisms of electrochemical deposition for copper and alternative interconnect metals, such as rhodium and iridium, specifically investigating nucleation and growth processes. A key area of focus involves analyzing how co-adsorption and competitive adsorption of additives, suppressors, surfactants, halides, anions, and cations influence metal deposition and interfacial structure. This initiative is part of the CHIPS Act project titled Electrodeposition of Interconnect Materials and Packaging and will be performed in Gaithersburg, Maryland. The opportunity is designated as a total small business set-aside under NAICS code 541713. Interested parties can coordinate through the point of contact, William Clark, regarding this forecast for laboratory program support.

AD for Laboratory Programs

POSTED

DEADLINE

Nuclear Technologies Development and Integration SupportThe National Nuclear Security Administration, an agency of the Department of Energy, has issued a forecast for Nuclear Technologies Development and Integration Support. This requirement falls under NAICS code 541713 and is slated for performance in Maryland. The current incumbent contractor for these services is the Johns Hopkins University Applied Physics Laboratory LLC. Interested parties can coordinate with Chelsea Murphy, the Small Business Program Manager, regarding this opportunity. The forecast was posted on August 16, 2026, and is categorized as an other type of set-aside.

National Nuclear Security Administration

POSTED

DEADLINE

STATE OF THE ART (SOTA) MICROELECTRONICS (ME) ADOPTION BROAD AGENCY ANNOUNCEMENT (BAA) FULL TEXT GENERAL ANNOUNCEMENT

Solicitation # 26S1358

The U.S. Department of the Air Force, through SAF/AQC, is issuing a Broad Agency Announcement (BAA) numbered 26-S-1358 to advance the adoption of state-of-the-art microelectronics across national security missions. This BAA does not solicit proposals directly but serves as an umbrella framework for future Topic Calls published on SAM.gov and the Classified IC-ARC, which will define specific technical requirements, submission deadlines, and evaluation criteria. The initiative focuses on accelerating the development and integration of trusted, assured microelectronics technologies, particularly those leveraging Intel 18A process nodes and advanced packaging via Secure Enclave, to ensure enduring technological superiority. Five key mission areas are highlighted: advanced secure microelectronics design and production; next-generation assembly, packaging, and test; novel microelectronics for disruptive capabilities; advanced test, validation, and mission qualification; and building an accessible, affordable, and sustainable domestic microelectronics ecosystem. Topics range from AI/ML architectures and radiation-hardened designs to chiplet-based systems, secure test methodologies, edge computing, RF electronics, PNT resilience, digital twins, and open-standard chiplet libraries. Proposals or White Papers may only be submitted in response to individual Topic Calls, which may be either closed (with fixed deadlines) or open (accepting submissions continuously during a defined window), and may follow one-step or two-step processes. Awards, if made, will take the form of procurement contracts or Other Transaction Agreements (OTAs) for prototyping, follow-on production, or experimental purposes, with eligibility open to small businesses, traditional and non-traditional defense contractors, and research institutions. OTA awards require resource-sharing commitments and participation by nontraditional contractors, small businesses, or third-party funding. Proposals must not include classified information unless explicitly directed by a classified Topic Call, which may require SECRET or higher clearances and approved secure facilities. Data rights are anticipated to include Government Purpose Rights for technical data and software, with specific terms negotiated per call. All submissions must reference the BAA number 26-S-1358 and be aligned with the specified Areas of Interest in each Topic Call. Interested parties must actively monitor SAM.gov and IC-ARC for updates, as Topic Calls may be issued throughout the BAA’s open period—initially one year, extendable annually—and any associated costs for proposal development are considered indirect, not chargeable to resulting contracts.

Department Of The Air Force

POSTED

DEADLINE

ERIS Shopping Notice: High Duty Cycle High Energy Lasers (HEL) for SWaP-Constrained Systems

Solicitation # DARPA-SN-26-82

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Defense Advanced Research Projects Agcy

POSTED

DEADLINE

Non-Profit Research Institution PartnerThis subcontract opportunity is for a non-profit research organization to partner with prime contractors on National Science Foundation SBIR/STTR projects. The selected partner will perform core scientific research and development focused on pharmaceutical or biologic innovations, utilizing bioreactors, laboratory facilities, and analytical chemistry equipment to advance intellectual merit. Key responsibilities include developing prototypes or proofs-of-concept and validating technical feasibility, with final deliverables consisting of research data, technical reports, and validated prototypes. The project is designated as a Total Small Business Set-Aside under the SBIR/STTR mandate for organizations with fewer than 500 employees, falling under NAICS code 541713. The solicitation was posted on May 22, 2026, and the deadline for responses is July 7, 2027.

National Science Foundation

POSTED

DEADLINE

NSF 26-510 | Augmented Virtual and Mixed Reality (AV/VR/MR) — Differentiated Hardware Technologies for AR/VR/MR

Solicitation # nsf-seedfund-AV-AV1_STTR

The National Science Foundation is seeking proposals under solicitation nsf-seedfund-AV-AV1_STTR for the development of innovative and differentiated hardware and software within the Augmented, Virtual, and Mixed Reality sectors. This initiative targets early-stage entrepreneurs and startups aiming to translate research-based insights into scalable, commercial applications. Key focus areas include the integration of AI for education, workforce development, health and wellbeing, and the creation of platforms for virtual collaboration and experiential learning. This opportunity is a total small business set-aside, specifically mandated for SBIR/STTR participants with fewer than 500 employees. The primary objective is to support the creation of novel technologies that enable shared experiences and provide tools for upskilling an aging workforce or improving general wellness. Interested parties can find further details through the National Science Foundation seed fund portal.

National Science Foundation

POSTED

5 months ago

DEADLINE

N/A

General Info

Agency

Department Of Defense → Army Medical Resources Acq Activity

NAICS

541713 - Research and Development in Nanotechnology

Place of Performance

Silver Spring, MD, 20910, USA

Set-Aside

NONE

Documents

PANDHA-26-P-0000 Notice of Intent to Sole Source - University of Notre Dame

justification-and-authorization

Low

RFI Antibacterial Nanoparticles Therapeutic Study PANDHA-26-P-0000

rfi

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

1 update

PhaseClosed

PostedMar 18

Sources Sought

Notice updatedApr 14

Notice type changed from Sources Sought to Special Notice. Response deadline changed from Apr 1, 2026 to Apr 28, 2026. The notice description changed.

Response DeadlineApr 28

Deadline has passed

Submission Closed

04/28/2026, 06:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Defense → Army Medical Resources Acq Activity

Contacts2 people available

OfficeFORT DETRICK, MD, 21702, USA

Organization / AgencyDepartment Of Defense → Army Medical Resources Acq Activity

Office AddressFORT DETRICK, MD, 21702, USA

Contacts

Linda Hinson

contact@example.gov

Sharew Hailu

contact@example.gov

Full Description

The University of Notre Dame will conduct a study to test innovative antibacterial nanoparticles with phage-mimicking properties (PhANPs) against combat relevant multi-drug resistant (MDR) strains of Pseudomonas (P.) aeruginosa, bacterial pathogen to cause hard to treat and even deadly infections in service members after battlefield injuries. There is a need to bring novel therapeutics to the military health care to treat MDR P. aeruginosa. The collaborative partner of this study is the University of Notre Dame, the patent owner of a unique technology (phage-mimicking nanoparticles) that provides life-saving therapeutics for service members and civilians. This technology was awarded a patent in 2024 - US-12161725-B2. Government anticipates that the collaborative efforts will contribute to Food and Drug Administration (FDA) approval of this innovative therapy, leading to reduced morbidity and mortality rates, enhanced operational readiness, advanced combat medicine, and substantial contributions to broader biosecurity initiatives and civilian health improvements.