Autonomous Physiological Closed-Loop Control (PCLC) Algorithm Development

The contract focuses on the design and development of control algorithms aimed at autonomously adjusting ventilator settings, such as positive end-expiratory pressure (PEEP), by utilizing real-time physiological data including oxygen saturation and lung compliance. This effort is intended to enhance ventilator performance through closed-loop control systems that respond dynamically to patient-specific conditions. The subcontract is issued by the Department of Defense's Defense Health Agency and is associated with NAICS code 541512, which covers computer systems design services. The work will be performed in Frederick, with a submission deadline for responses set for June 22, 2026. This project underscores a critical advancement in medical device automation, seeking to improve patient outcomes through sophisticated algorithmic control of ventilation therapy. No specific set-aside or organization type restrictions are indicated, and the opportunity emphasizes the integration of physiological monitoring with automated control technology in healthcare settings.