Bioinformatics Analysis of Livestock Genomics

The contract solicitation for Bioinformatics Analysis of Livestock Genomics, identified by solicitation number 75F40126Q00206, is a firm fixed-price procurement issued by the FDA Office of Acquisitions and Grants Services under the Department of Health and Human Services, exclusively set aside for small businesses as a Total Small Business Set-Aside under NAICS code 518210. The work involves performing visual validation of 2,000 swine variants from an existing candidate list and generating CRISPRme-compatible VCF files for cattle, chicken, and swine using the precisionFDA platform, which is mandatory for all data transfer between the contractor and the Center for Veterinary Medicine. The project requires direct performance by the offeror with no subcontracting permitted, and all bioinformatics analysis must be conducted within the United States. The contractor must establish a precisionFDA account prior to or within five business days of contract award, adhere to strict data handling protocols under FAR 52.239-1, comply with Section 508 accessibility standards, and ensure all computational workflows are version-controlled using Git and containerized with Docker or Conda. The contract includes a one-year base period from July 15, 2026, to July 14, 2027, with no option periods, and requires submission of a Quality Assurance Plan, detailed validation protocols, monthly status reports, and deliverables such as executable scripts and documented analytical decisions that meet scientifically sound and reproducible standards. All proposals must be submitted via email to Samad Sahil by 3:00 PM Eastern Time on June 29, 2026, and must demonstrate a clear, logical technical approach addressing the Statement of Work sections on specific requirements, deliverables, and special instructions, particularly Section 8.5. Proposals that fail to meet mandatory pass/fail gates—such as self-performance, U.S.-based data analysis, or lack of compliance with VCF and CRISPRme specifications—will be deemed unacceptable and disqualified. Pricing must be structured by fixed-price contract line items for variant validation, CRISPRme-ready VCF generation for two pig breeds, and potential additional species or breeds. The Government will evaluate proposals using a trade-off process to select the best combination of technical superiority and low risk, with payment issued electronically through the Treasury’s Invoice Processing Platform upon formal acceptance of deliverables by the Contracting Officer. The contractor must comply