This Solicitation opportunity from Department Of Defense was posted on October 1, 2025. The submission period has ended. Browse the details below for market research, or find similar active opportunities.

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Biological Technologies

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HR001126S0003Federal

Submission Closed09/30/2026, 12:00:00 PM UTC

Contract Overview

Solicitation details, issuing organization, response deadlines, documents, and interested companies for this government contract opportunity.

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NAICS: 541714

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Blood-Based Biomarker Validation & ScalingThis subcontract focuses on the validation and scaling of blood-based biomarkers to support prime contractors within the Defense Health Agency Alzheimer’s Research Program. The scope of work involves performing detailed laboratory analysis of blood samples, validating the sensitivity and specificity of assays, and establishing scalable testing protocols. These operations must utilize Simoa equipment and biobanking systems while adhering strictly to GLP standards and maintaining CLIA certification. The project is managed under the Department of Defense and is centered in Frederick, Maryland. The primary objective is the delivery of validated, scalable biomarker assays and protocols to advance research goals. Interested parties should note the response deadline of December 4, 2026, and the classification of the work under NAICS code 541714.

Defense Health Agency

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DEADLINE

RFI Alzheimer’s Research Program (AZRP) Public

Solicitation # HT9427RFI2027AZRP

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Solicitation # HT9427RFI2027TBIPHRP

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Solicitation # USDA-NIFA-TOPIC-8.2

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Advanced Research Projects Agency For Health (arpa-H)

POSTED

DEADLINE

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POSTED

DEADLINE

AAV Vector Binding and Internalization Testing (Kidney Tissue)This subcontract, issued by the Department of Veterans Affairs Rpo East for biotechnology projects at the Harry S Truman Memorial Veterans Hospital, involves specialized laboratory testing to verify the binding and internalization of AAV vectors. The selected provider will be responsible for preparing kidney tissue slices, incubating them with modified AAV vectors, and utilizing qPCR platforms, Agilent Fragment Analyzers, and fluorescence microscopy to analyze efficiency. All work must be performed in BSL-2 facilities, and the contractor is required to hold BSL-2 certification. The primary deliverable for this engagement is the provision of detailed validation reports focusing on internalization rates and binding affinity. The project is categorized under NAICS code 541714 and is based in Columbia, Missouri. Interested parties must respond by November 4, 2026.

Rpo East (36C24E)

POSTED

7 days ago

DEADLINE

in 7 days

AI Contract Overview

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is soliciting proposals under Broad Agency Announcement HR001126S0003 to leverage biological properties and processes to revolutionize warfighter protection. The effort focuses on transformative science rather than evolutionary improvements, specifically targeting three functional areas: materials, sensors, and processing; agricultural and environmental stability; and security, safety, and surveillance. Key research goals include developing novel bio-inspired materials, utilizing AI/ML for biological data modeling, optimizing human performance, and enhancing the detection of emerging pathogens. Awards may be issued as procurement contracts, cooperative agreements, or Other Transaction Agreements for research or prototypes. Proposals are evaluated based on overall scientific and technical merit, potential contribution to the DARPA mission, and cost and schedule realism. The submission process requires a mandatory two-page abstract followed by a full proposal consisting of a technical and management volume and a cost volume. Proposers must use specific DARPA templates and a streamlined cost proposal spreadsheet. For efforts not exceeding 2 million dollars, an accelerated award option is available to expedite the process to within 30 days of selection. The contract emphasizes strict adherence to Controlled Unclassified Information (CUI) guidelines and requires the use of Wide Area Workflow (WAWF) for electronic invoicing and payment.

General Info

DARPA seeks proposals for transformative biological technologies to enhance warfighter protection and security.

Agency

Department Of Defense → Defense Advanced Research Projects Agcy

NAICS

541714 - Research and Development in Biotechnology (except Nanobiotechnology)

Place of Performance

Set-Aside

NONE

Documents

Contract HR00112CXXX Accelerated Baseline Model Small Business

contract-document

High

Contract HR00112CXXX Award Document

contract-document

High

DARPA BTO Broad Agency Announcement HR001126S0003 Biological Technologies

baa

High

HR001126S0003 Abstract Submission Template for Biological Technologies BAA

abstract-template

High

HR001126S0003 Attachment C Volume II Cost Proposal Instructions and Template

cost-proposal-template

High

HR001126S0003 Attachment G Accelerated Award Option Election and Attestation Form

attachment

High

HR001126S0003 Baseline Model Contract Addendum

contract-document

High

HR001126S0003 Biological Technologies Proposal Instructions and Volume I Template

proposal-instructions-template

High

HR001126S0003 Classified Submission Instructions

submission-instructions

High

HR001126S0003 Cooperative Agreement V2

cooperative-agreement

High

HR001126S0003 DARPA Model Other Transaction Agreement for Prototype

contract-document

High

HR001126S0003 DARPA Streamlined Cost Proposal Spreadsheet V3

cost-proposal-spreadsheet

High

HR001126S0003 Model Other Transaction Agreement for Research

contract-document

High

HR001126S0003 Controlled Unclassified Information Guide

other

Low

AI Contract Breakdown

Uniform Contract Format

Timeline

PhaseClosed

PostedOct 1

Solicitation

Response DeadlineSep 30

Deadline has passed

Submission Closed

09/30/2026, 12:00:00 PM UTC

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Organization & Contact Information

AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Contacts1 person available

OfficeARLINGTON, VA, 222032114, USA

Organization / AgencyDepartment Of Defense → Defense Advanced Research Projects Agcy

Office AddressARLINGTON, VA, 222032114, USA

Contacts

BAA Coordinator

contact@example.gov

Full Description

The Defense Advanced Research Projects Agency (DARPA) Biological Technologies Office (BTO) is soliciting proposals that leverage biological properties and processes to revolutionize our ability to protect the nation’s warfighters. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.