Carcinogen Hazard Assessment Monographs Program (CHAMP) (R01 Clinical Trial Not Allowed)

The National Cancer Institute, under the Department of Health and Human Services, is soliciting proposals for the Carcinogen Hazard Assessment Monographs Program (CHAMP) through solicitation RFA-CA-28-013. This initiative seeks to establish a program that critically and systematically evaluates scientific evidence regarding carcinogenic hazards to humans to inform global cancer research, control, and prevention efforts. The awarded entity will lead integrative scientific efforts to identify cancer hazards, convene and provide administrative support for five to seven interdisciplinary working groups, and produce high-quality, authoritative Monographs for dissemination to the public and global health agencies, with a particular focus on low- and middle-income communities. Applications are subject to a merit-based review process focusing on the importance of the research, scientific rigor, feasibility, and the expertise of the investigators and their institutional environment. Key requirements include the use of systematic reviews and strength-of-the-evidence evaluations, strict adherence to conflict-of-interest safeguards, and the implementation of a robust data management and sharing plan. Eligible applicants must maintain active registrations in SAM, eRA Commons, and Grants.gov, and all Principal Investigators must have a linked ORCID ID. Notably, applications involving foreign subawards or subcontracts are deemed noncompliant. The NCI intends to fund one award with a potential budget of up to 700,000 dollars in total direct costs per year for a project period of up to five years, with an intended commitment of 800,000 dollars in FY 2028. The response deadline for this opportunity is February 9, 2027.